ACP3 - acid phosphatase 3 Gene

中文名称：酸性磷酸酶 3

种属: Homo sapiens

同用名: ACPP; 5'-NT; ACP-3; TM-PAP

基因 ID: 55 | 基因类型: protein coding

关于 ACP3

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:132,317,407-132,368,302 (from NCBI)

This gene has 9 transcripts (splice variants), 165 orthologues and 5 paralogues. Restricted expression toward prostate (RPKM 1149.8).

功能概要

该基因编码的酶可催化正磷酸单酯转化为醇和正磷酸盐。它是在雄激素调节下合成的，由前列腺的上皮细胞分泌。已为该基因发现编码更长同种型的可变剪接转录物变体。该亚型包含一个跨膜结构域，位于质膜-内体-溶酶体途径中。[RefSeq 提供，2008 年 9 月]

This gene encodes an Enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]

ACP3 基因产物(3)

mRNA	Protein	Name
NM_001099.5	NP_001090.2	prostatic acid phosphatase isoform PAP precursor
NM_001134194.2	NP_001127666.1	prostatic acid phosphatase isoform TM-PAP precursor
NM_001292037.2	NP_001278966.1	prostatic acid phosphatase isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 5'-nucleotidase activity	IDA IDA: 通过直接分析推断	18940592	GOA
enables acid phosphatase activity	IDA IDA: 通过直接分析推断	10506173	GOA
enables acid phosphatase activity	IMP IMP: 通过突变表型推断	8132635	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	18083097	GOA
enables lysophosphatidic acid phosphatase activity	IDA IDA: 通过直接分析推断	15280042	GOA
enables molecular adaptor activity	EXP EXP: 通过实验结果推断	19995078	GOA
enables phosphatase activity	IMP IMP: 通过突变表型推断	18940592	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9705354	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	10639192	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in adenosine metabolic process	IDA IDA: 通过直接分析推断	18940592	GOA
involved in dephosphorylation	IMP IMP: 通过突变表型推断	8132635	GOA
involved in positive regulation of adenosine receptor signaling pathway	IMP IMP: 通过突变表型推断	18940592	GOA
involved in regulation of sensory perception of pain	IMP IMP: 通过突变表型推断	18940592	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	10639192	GOA
located in extracellular space	IMP IMP: 通过突变表型推断	22389722	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	17658863	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ACP3 蛋白结构

His_Phos_2

0
100
200
300
386 a.a.

蛋白主名

其他名称

prostatic acid phosphatase

TMPase

ACP3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ACP3	P15309	ERBB2	Homo sapiens	P04626	Genetic Interference	9705354
种属内	ACP3	P15309	ERBB2	Homo sapiens	P04626	Phosphatase Assay	9705354
种属内	ACP3	P15309	ACP3	Homo sapiens	P15309	Fluorescence	24657436
种属内	ACP3	P15309	ACP3	Homo sapiens	P15309	Cosedimentation	18083097
种属内	ACP3	P15309	ACP3	Homo sapiens	P15309	TEM	24657436
种属内	ACP3	P15309	ACP3	Homo sapiens	P15309	CD	18083097

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ACP3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7817	Prostatic acid phosphatase/ACPP Protein, Human (354a.a, HEK293, His, solution)	AAH16344.1 (K33-D386)	≥95%
HY-P7817A	Prostatic acid phosphatase/ACPP Protein, Human (HEK293, His)	NP_001127666.1 (K33-K382)	≥95%
HY-P700619	Prostatic acid Phosphatase/ACPP Protein, Human (HEK293, GFP-His)	P15309 (K33-K382)	≥95%
HY-P700620	Prostatic acid Phosphatase/ACPP Protein-VLP, Human (386a.a, HEK293, His)	P15309 (K33-I418)	≥95%

ACP3 抗体

目录号	产品名	应用	反应物种
HY-P81961	Prostatic Acid Phosphatase Antibody (YA1706)	WB, IHC-P, ICC/IF, IP	Human

关联疾病

疾病名称

别名

Prostatitis

Clear Cell Adenocarcinoma

Mesonephroma	Water-Clear Cell Adenocarcinoma
Adenocarcinoma, Clear Cell	Malignant Mesonephroma
Mesonephroid Clear Cell Carcinoma	Mesonephroma, Malignant
Water-Clear Cell Carcinoma	Wolffian Duct Neoplasm
Adenocarcinoma Clear Cell	Mesonephric Tumor

Atypical Choroid Plexus Papilloma

Atypical Papilloma Of Choroid Plexus

Atypical Cpp

Cerebrovascular Benign Neoplasm

Phosphatase, Acid, Of Tissues

Lysosomal Acid Phosphatase

Acp3--Alpha Polypeptide

Choroid Plexus Cancer

Choroid Plexus Carcinoma	Choroid Plexus Neoplasms
Choroid Plexus Neoplasm	Tumor Of Choroid Plexus
Tumor Of The Choroid Plexus	Choroid Plexus Tumor
Choroid Plexus Tumors	Anaplastic Choroid Plexus Papilloma
Choroid Plexus Papilloma Nos	Papilloma Of Choroid Plexus
Plexus Choroideus Papilloma	Choroid Plexus Papilloma In Fourth Ventricle
Plexus Choroideus Papilloma In Fourth Ventricle

Prostatic Hyperplasia, Benign

Benign Prostatic Hyperplasia	BPH
Prostatic Hyperplasia

Prostatic Adenoma

Prostatic Hyperplasia	Adenoma - Prostate
Adenoma Of Prostate	Benign Adenoma Of Prostate
Prostate Adenoma	Benign Prostatic Hyperplasia

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Combined Oxidative Phosphorylation Deficiency 17

COXPD17	Combined Oxidative Phosphorylation Defect Type 17
Combined Oxidative Phosphorylation Deficiency, Type 17

Prostate Disease

Prostatic Diseases

Prostate Diseases

Papilloma Of Choroid Plexus

Choroid Plexus Papilloma	CPP
Childhood Choroid Plexus Papilloma	Papilloma Choroid Plexus
Papilloma, Choroid Plexus	Choroid Plexus Carcinoma

Endodermal Sinus Tumor

Yolk Sac Tumor	Endodermal Sinus Tumour
Hepatoid Yolk Sac Tumour	Infantile Embryonal Carcinoma
Yolk Sac Neoplasm	Yolk Sac Tumour

Cerebral Ventricle Cancer

Cerebral Ventricle Neoplasms	Cerebral Ventricle Neoplasm
Intraventricular Tumor Of Brain

Cerebrum Cancer

Cerebral Cancer	Neoplasm Of Cerebrum
Tumor Of Cerebrum	Malignant Neoplasm Of Cerebrum

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00188	ACP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ACP3	RGD	RGD:2023
Bos taurus	ACP3	VGNC	VGNC:52603
Canis familiaris	ACP3	VGNC	VGNC:54915
Mus musculus	ACP3	MGD	MGI:1928480
Macaca mulatta	ACP3	VGNC	VGNC:69385
Felis catus	ACP3	VGNC	VGNC:59528
Others	ACP3	NCBI

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ACP3 - acid phosphatase 3 Gene

关于 ACP3

功能概要

ACP3 基因产物(3)

ACP3 蛋白结构

ACP3 蛋白互作信息

重组 ACP3 蛋白

ACP3 抗体

关联疾病

直系同源

热门区域

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ACP3 - acid phosphatase 3 Gene

关于 ACP3

功能概要

ACP3 基因产物(3)

ACP3 蛋白结构

ACP3 蛋白互作信息

重组 ACP3 蛋白

ACP3 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z