BANK1 - B cell scaffold protein with ankyrin repeats 1 Gene

中文名称：具有锚蛋白重复 1 的 B 细胞支架蛋白

种属: Homo sapiens

同用名: BANK

基因 ID: 55024 | 基因类型: protein coding

关于 BANK1

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:101,790,730-102,074,812 (from NCBI)

This gene has 8 transcripts (splice variants), 175 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in lymph node (RPKM 39.0), spleen (RPKM 27.4) and 8 other tissues.

功能概要

由该基因编码的蛋白质是一种 B 细胞特异性支架蛋白，在 B 细胞受体诱导的细胞内钙动员中发挥作用。这种蛋白质还可以促进 Lyn 介导的肌醇 1,4,5-三磷酸受体的酪氨酸磷酸化。该基因的多态性与系统性红斑狼疮的易感性有关。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 10 月]

The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

BANK1 基因产物(3)

mRNA	Protein	Name
NM_001083907.3	NP_001077376.3	B-cell scaffold protein with ankyrin repeats isoform 2
NM_001127507.3	NP_001120979.3	B-cell scaffold protein with ankyrin repeats isoform 3
NM_017935.5	NP_060405.5	B-cell scaffold protein with ankyrin repeats isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables phospholipase binding	IPI IPI: 通过物理相互作用推断	23555801	GOA
enables protease binding	IPI IPI: 通过物理相互作用推断	23555801	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11782428	GOA
enables protein tyrosine kinase binding	IPI IPI: 通过物理相互作用推断	11782428	GOA
enables signaling adaptor activity	IDA IDA: 通过直接分析推断	23555801	GOA
enables signaling receptor binding	IPI IPI: 通过物理相互作用推断	11782428	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in B cell activation	IDA IDA: 通过直接分析推断	11782428	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: 通过突变表型推断	11782428	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	23555801	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BANK1 蛋白结构

DBB

0
200
400
600
785 a.a.

蛋白主名

其他名称

B-cell scaffold protein with ankyrin repeats

BANK1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BANK1	Q8NDB2	BLK	Homo sapiens	P51451	Anti Bait CoIP	21978998
种属内	BANK1	Q8NDB2	BLK	Homo sapiens	P51451	Confocal	21978998
种属内	BANK1	Q8NDB2	BLK	Homo sapiens	P51451	Anti Tag CoIP	21978998
种属内	BANK1	Q8NDB2	LYN	Homo sapiens	P07948	Anti Bait CoIP	11782428
种属内	BANK1	Q8NDB2	LYN	Homo sapiens	P07948	Anti Tag CoIP	11782428
种属内	BANK1	Q8NDB2	LYN	Homo sapiens	P07948	Pull Down	11782428

种属间: 跨种属相互作用 种属内: 同种属相互作用

BANK1 抗体

目录号	产品名	应用	反应物种
HY-P81434	BANK1 Antibody (YA1179)	IHC-P	Human

关联疾病

疾病名称

别名

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Facial Hemiatrophy

Parry-Romberg Syndrome

Diffuse Scleroderma

Diffuse Systemic Sclerosis	Systemic Sclerosis, Diffuse
Scleroderma, Diffuse	Systemic Scleroderma
Progressive System Sclerosis

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01362	BANK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	BANK1	VGNC	VGNC:38377
Mus musculus	BANK1	MGD	MGI:2442120
Bos taurus	BANK1	VGNC	VGNC:106648
Macaca mulatta	BANK1	VGNC	VGNC:70090
Rattus norvegicus	BANK1	RGD	RGD:1564639
Felis catus	BANK1	VGNC	VGNC:78456

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BANK1 - B cell scaffold protein with ankyrin repeats 1 Gene

关于 BANK1

功能概要

BANK1 基因产物(3)

BANK1 蛋白结构

BANK1 蛋白互作信息

BANK1 抗体

关联疾病

直系同源

热门区域

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BANK1 - B cell scaffold protein with ankyrin repeats 1 Gene

关于 BANK1

功能概要

BANK1 基因产物(3)

BANK1 蛋白结构

BANK1 蛋白互作信息

BANK1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z