1. Gene
  2. DET1 - DET1 partner of COP1 E3 ubiquitin ligase Gene

DET1 - DET1 partner of COP1 E3 ubiquitin ligase Gene

中文名称:COP1 E3 泛素连接酶的 DET1 伙伴

种属: Homo sapiens

基因 ID: 55070 | 基因类型: protein coding

关于 DET1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:88,501,919-88,546,703 (from NCBI)

This gene has 8 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in ovary (RPKM 4.8), endometrium (RPKM 3.7) and 25 other tissues.

功能概要

启用泛素连接酶-底物接头活性和泛素蛋白连接酶结合活性。参与蛋白酶体泛素依赖性蛋白质分解代谢过程的正调控;蛋白质泛素化;和含蛋白质的复杂组装。 Cul4A-RING E3 泛素连接酶复合物的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables ubiquitin ligase-substrate adaptor activity and ubiquitin protein Ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and protein-containing complex assembly. Part of Cul4A-RING E3 ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

DET1 基因产物(4)

mRNA Protein Name
NM_001144074.3 NP_001137546.1 DET1 homolog isoform 2
NM_001321594.2 NP_001308523.1 DET1 homolog isoform 3
NM_001321596.1 NP_001308525.1 DET1 homolog isoform 2
NM_017996.5 NP_060466.2 DET1 homolog isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14739464 GOA
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
14739464 GOA
enables ubiquitin protein ligase binding IMP
IMP: 通过突变表型推断
14739464 GOA
enables ubiquitin-like ligase-substrate adaptor activity IPI
IPI: 通过物理相互作用推断
14739464 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IPI
IPI: 通过物理相互作用推断
14739464 GOA
involved in protein ubiquitination IPI
IPI: 通过物理相互作用推断
14739464 GOA
involved in protein-containing complex assembly IDA
IDA: 通过直接分析推断
14739464 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul4-RING E3 ubiquitin ligase complex IDA
IDA: 通过直接分析推断
16949367 GOA
part of Cul4A-RING E3 ubiquitin ligase complex IDA
IDA: 通过直接分析推断
14739464 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DET1 蛋白结构

Det1

Det1: De-etiolated protein 1 Det1 (142 - 547)

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  • 550 a.a.
蛋白主名 其他名称

DET1 homolog

DET1, COP1 ubiquitin ligase partner

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DET1 VGNC VGNC:49598
Rattus norvegicus DET1 RGD RGD:1309793
Mus musculus DET1 MGD MGI:1923625
Macaca mulatta DET1 VGNC VGNC:99197
Felis catus DET1 VGNC VGNC:80989
Bos taurus DET1 VGNC VGNC:49548