1. Gene
  2. BRF2 - BRF2 RNA polymerase III transcription initiation factor subunit Gene

BRF2 - BRF2 RNA polymerase III transcription initiation factor subunit Gene

中文名称:BRF2 RNA 聚合酶 III 转录起始因子亚基

种属: Homo sapiens

同用名: BRFU; TFIIIB50

基因 ID: 55290 | 基因类型: protein coding

关于 BRF2

Cytogenetic location: 8p11.23 Genomic coordinates (GRCh38): 8:37,843,268-37,849,861 (from NCBI)

This gene has 4 transcripts (splice variants), 192 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 46.9), prostate (RPKM 42.0) and 24 other tissues.

功能概要

该基因编码 RNA 聚合酶 III 转录因子复合物的多个亚基之一,该复合物是转录具有起始位点上游启动子元件的基因所必需的。该基因的产物,一种 TFIIB 样因子,通过与 TATA 结合蛋白的相互作用,被直接募集到聚合酶 III 小核 RNA 基因启动子的 TATA 盒中。[RefSeq 提供,2008 年 7 月]

This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]

BRF2 基因产物(1)

mRNA Protein Name
NM_018310.4 NP_060780.2 transcription factor IIIB 50 kDa subunit
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase III type 3 promoter sequence-specific DNA binding IDA
IDA: 通过直接分析推断
26638071 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to oxidative stress IMP
IMP: 通过突变表型推断
26638071 GOA
involved in regulation of transcription by RNA polymerase III IMP
IMP: 通过突变表型推断
26638071 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of transcription factor TFIIIB complex IMP
IMP: 通过突变表型推断
26638071 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BRF2 蛋白结构

TF_Zn_Ribbon

TF_Zn_Ribbon: TFIIB zinc-binding (6 - 37)

  • 0
  • 100
  • 200
  • 300
  • 419 a.a.
蛋白主名 其他名称

transcription factor IIIB 50 kDa subunit

B-related factor 2

BRF2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BRF2 Q9HAW0 JUP Homo sapiens P14923 33961781
种属内
BRF2 Q9HAW0 JUP Homo sapiens P14923 28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cone-Rod Dystrophy 9

CORD9

Dystrophy, Cone-Rod, Type 9

Retinitis Pigmentosa 9

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus BRF2 RGD RGD:1308817
Felis catus BRF2 VGNC VGNC:60173
Macaca mulatta BRF2 VGNC VGNC:70335
Mus musculus BRF2 MGD MGI:1913903
Bos taurus BRF2 VGNC VGNC:26563
Canis familiaris BRF2 VGNC VGNC:38524