AVPR1B - arginine vasopressin receptor 1B Gene

中文名称：精氨酸加压素受体 1B

种属: Homo sapiens

同用名: V1bR; VPR3; AVPR3

基因 ID: 553 | 基因类型: protein coding

关于 AVPR1B

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,106,936-206,117,388 (from NCBI)

This gene has 2 transcripts (splice variants), 132 orthologues and 16 paralogues. Low expression observed in reference dataset.

功能概要

由该基因编码的蛋白质充当精氨酸加压素的受体。该受体属于 G 蛋白偶联受体亚家族，其中包括 AVPR1A、V2R 和 OXT 受体。其活性由刺激磷脂酰肌醇-钙第二信使系统的 G 蛋白介导。该受体主要位于垂体前叶，可刺激 ACTH 释放。它在分泌 ACTH 的垂体腺瘤以及导致异位 ACTH 综合征的支气管类癌中高水平表达。已报道该基因的剪接反义转录本，但其功能尚不清楚。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]

AVPR1B 基因产物(1)

mRNA	Protein	Name
NM_000707.5	NP_000698.1	vasopressin V1b receptor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables vasopressin receptor activity	IDA IDA: 通过直接分析推断	9322919	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	15528211	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	9322919	GOA
involved in positive regulation of MAPK cascade	IDA IDA: 通过直接分析推断	9322919	GOA
involved in positive regulation of arachidonate secretion	IDA IDA: 通过直接分析推断	9322919	GOA
involved in positive regulation of inositol phosphate biosynthetic process	IDA IDA: 通过直接分析推断	9322919	GOA
involved in positive regulation of phospholipase A2 activity	IDA IDA: 通过直接分析推断	9322919	GOA
involved in regulation of cell population proliferation	IDA IDA: 通过直接分析推断	9322919	GOA
involved in symbiont entry into host cell	IDA IDA: 通过直接分析推断	33713620	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	15528211	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	15528211	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AVPR1B 蛋白结构

7tm_1

0
100
200
300
400
424 a.a.

蛋白主名

其他名称

vasopressin V1b receptor

AVPR V1b	AVPR V3
V1B receptor	antidiuretic hormone receptor 1B
arginine vasopressin receptor 3	pituitary vasopressin receptor 3
vasopressin V3 receptor

关联疾病

疾病名称

别名

Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus	Diabetes Insipidus, Nephrogenic
Diabetes Insipidus Nephrogenic	Congenital Nephrogenic Diabetes Insipidus
Adh Resistant Diabetes Insipidus	Diabetes Insipidus Nephrogenic X-Linked
Diabetes Insipidus Nephrogenic Type 1	Adh-Resistant Diabetes Insipidus
Diabetes Insipidus Renalis	Ndi
Renal Diabetes Insipidus	Familial Nephrogenic Diabetes
Antidiuretic-Hormone-Resistant Diabetes Insipidus	Adiuretin-Resistant Diabetes Insipidus
Ndi - [Nephrogenic Diabetes Insipidus]	Diabetes Tenuifluus
Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus	Hereditary Nephrogenic Diabetes Insipidus
Familial Nephrogenic Diabetes Insipidus	Primary Nephrogenic Diabetes Insipidus

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Diabetes Insipidus

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Adrenal Cortex Adenoma	Corticotroph Pituitary Adenoma
Cushing'S Disease	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Asperger Syndrome

Asperger Disorder

Diabetes Insipidus, Neurohypophyseal

Neurohypophyseal Diabetes Insipidus	Central Diabetes Insipidus
Cdi	Pituitary Diabetes Insipidus
Vasopressin Defective Diabetes Insipidus	Vasopressin Deficiency
Diabetes Insipidus, Neurogenic	Diabetes Insipidus, Primary Central
Diabetes Insipidus, Cranial Type	Diabetes Insipidus Secondary To Vasopressin Deficiency
Diabetes Insipidus, Central	Diabetes Insipidus, Pituitary
NDI	Diabetes Insipidus Cranial Type
Neurogenic Diabetes Insipidus	Primary Central Diabetes Insipidus

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-P0049A	Argipressin diacetate		/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01284	AVPR1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01285	Avpr1b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01286	Avpr1b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	AVPR1B	VGNC	VGNC:38319
Macaca mulatta	AVPR1B	VGNC	VGNC:70198
Rattus norvegicus	AVPR1B	RGD	RGD:6502812
Felis catus	AVPR1B	VGNC	VGNC:68844
Mus musculus	AVPR1B	MGD	MGI:1347010
Bos taurus	AVPR1B	VGNC	VGNC:26359

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AVPR1B - arginine vasopressin receptor 1B Gene

关于 AVPR1B

功能概要

AVPR1B 基因产物(1)

AVPR1B 蛋白结构

关联疾病

直系同源

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AVPR1B - arginine vasopressin receptor 1B Gene

关于 AVPR1B

功能概要

AVPR1B 基因产物(1)

AVPR1B 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z