2. Gene
  3. RFK - riboflavin kinase Gene

RFK - riboflavin kinase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核黄素激酶

种属: Homo sapiens

同用名: RIFK

基因 ID: 55312 | 基因类型: protein coding

关于 RFK

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:76,385,526-76,394,426 (from NCBI)

This gene has 6 transcripts (splice variants) and 253 orthologues. Ubiquitous expression in colon (RPKM 20.2), duodenum (RPKM 17.4) and 25 other tissues.

功能概要

核黄素激酶 (RFK; EC 2.7.1.26) 是一种必需的酶，可催化核黄素 (维生素 B2) 磷酸化形成黄素单核苷酸 (FMN) ，这是维生素 B2 利用和黄素辅助因子合成的必要步骤 (Karthikeyan 等人，2003 年) [PubMed 12623014]) .[OMIM 提供，2009 年 11 月]

Riboflavin kinase (RFK; EC 2.7.1.26) is an essential Enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]).[supplied by OMIM, Nov 2009]

RFK 基因产物(1)

mRNA Protein Name
NM_018339.6 NP_060809.3 riboflavin kinase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19641494 GOA
enables riboflavin kinase activity IDA
IDA: 通过直接分析推断
19641494 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic process IMP
IMP: 通过突变表型推断
19641494 GOA
acts upstream of or within positive regulation of NAD(P)H oxidase activity IMP
IMP: 通过突变表型推断
19641494 GOA
involved in riboflavin metabolic process IDA
IDA: 通过直接分析推断
19641494 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RFK 蛋白结构

Flavokinase

Flavokinase: Riboflavin kinase (4 - 130)

  • 0
  • 100
  • 155 a.a.
蛋白主名 其他名称

riboflavin kinase

0610038L10Rik

RFK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RFK Q969G6 TNFRSF1A Homo sapiens P19438
Pull Down
19641494
种属内
RFK Q969G6 CNTLN Homo sapiens Q9NXG0-2
Y2H Prey Pooling
32296183
种属内
RFK Q969G6 CNTLN Homo sapiens Q9NXG0-2
Validated Y2H
32296183
种属内
RFK Q969G6 CNTLN Homo sapiens Q9NXG0-2
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 RFK 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73677 RFK Protein, Human (His) Q969G6 (M1-H155) ≥95%

关联疾病

疾病名称 别名
Riboflavin Deficiency

Ariboflavinosis

Maternal Riboflavin Deficiency

RBFVD

Vitamin B2 Deficiency

Hyporiboflavinosis
Brown-Vialetto-Van Laere Syndrome
Fazio-Londe Disease

Fazio-Londe Syndrome

Riboflavin Transporter Deficiency Neuronopathy

Brown-Vialetto-Van Laere Syndrome

Progressive Bulbar Palsy Of Childhood

Bulbar Palsy, Progressive, Of Childhood

Bvvls

Pontobulbar Palsy With Deafness

Progressive Bulbar Palsy With Sensorineural Deafness

Riboflavin Transporter Deficiency

FALOND

Bulbar Palsy Progressive Of Childhood

Bulbar Palsy Of Childhood, Progressive
Multiple Acyl-Coa Dehydrogenase Deficiency

MADD

Ethylmalonic-Adipicaciduria

Ema

Glutaric Acidemia Iia

Glutaric Acidemia Iib

Ga Ii

Glutaric Acidemia Iic

Glutaric Acidemia Type 2

Glutaric Acidemia Ii

Glutaric Aciduria Ii

Electron Transfer Flavoprotein Deficiency

Glutaric Aciduria Type 2

Mad Deficiency

Glutaric Acidemia Type Ii

Glutaric Aciduria 2

Etfa Deficiency

Etfb Deficiency

Etfdh Deficiency

Multiple Acyl Coenzyme A Dehydrogenase Deficiency

Ga2

Electron Transfer Flavoprotein Ubiquinone Oxidoreductase Deficiency

Electron Transfer Flavoprotein Dehydrogenase Deficiency

Ga 2

Glutaric Acidemia 2

Glutaric Acidemia, Type 2

Glutaric Aciduria, Type 2

Mad

Multiple Fad Dehydrogenase Deficiency

Ethylmalonic Adipic Aciduria

Glutaricaciduria Ii

Glutaric Aciduria 2a

GA2A

Gaiia

Glutaricaciduria Iia

Glutaric Aciduria 2b

GA2B

Gaiib

Glutaricaciduria Iib

Glutaric Aciduria 2c

GA2C

Gaiic

Glutaricaciduria Iic

Glutaricaciduria, Type Iia

Glutaric Acidemia Type 2a

Glutaric Acidemia Type 2c

Glutaric Aciduria Iia

Glutaric Aciduria Iib

Glutaric Aciduria Iic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11872 RFK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RFK VGNC VGNC:54852
Rattus norvegicus RFK RGD RGD:1549748
Mus musculus RFK MGD MGI:1914688
Felis catus RFK VGNC VGNC:102975
Bos taurus RFK VGNC VGNC:33891
Others RFK NCBI
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