1. Gene
  2. SUPT20H - SPT20 homolog, SAGA complex component Gene

SUPT20H - SPT20 homolog, SAGA complex component Gene

中文名称:SPT20 同源物,SAGA 复杂成分

种属: Homo sapiens

同用名: C13; FP757; P38IP; SPT20; FAM48A; C13orf19

基因 ID: 55578 | 基因类型: protein coding

关于 SUPT20H

Cytogenetic location: 13q13.3 Genomic coordinates (GRCh38): 13:37,009,312-37,059,688 (from NCBI)

This gene has 23 transcripts (splice variants), 212 orthologues and 2 paralogues. Broad expression in testis (RPKM 29.4), endometrium (RPKM 11.5) and 25 other tissues.

功能概要

预测启用转录共调节因子活动。预计参与 RNA 聚合酶 II 的转录调控。预测作用于糖异生正调控和 RNA 聚合酶 II 转录正调控的上游或内部。 SAGA 型建筑群的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of gluconeogenesis and positive regulation of transcription by RNA polymerase II. Part of SAGA-type complex. [provided by Alliance of Genome Resources, Apr 2022]

SUPT20H 基因产物(5)

mRNA Protein Name
NM_001014286.3 NP_001014308.2 transcription factor SPT20 homolog isoform a
NM_001278480.2 NP_001265409.1 transcription factor SPT20 homolog isoform c
NM_001278481.2 NP_001265410.1 transcription factor SPT20 homolog isoform b
NM_001278482.2 NP_001265411.1 transcription factor SPT20 homolog isoform b
NM_017569.4 NP_060039.1 transcription factor SPT20 homolog isoform b
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16713569 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SAGA-type complex IDA
IDA: 通过直接分析推断
18838386 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SUPT20H 蛋白结构

Spt20

Spt20: Spt20 family (62 - 221)

  • 0
  • 200
  • 400
  • 600
  • 779 a.a.
蛋白主名 其他名称

transcription factor SPT20 homolog

family with sequence similarity 48, member A

SUPT20H 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SUPT20H Q8NEM7 MAPK14 Homo sapiens Q16539
Y2H Pooling
20936779
种属内
SUPT20H Q8NEM7 MAPK14 Homo sapiens Q16539
Anti Bait CoIP
16751104
种属内
SUPT20H Q8NEM7 MAPK14 Homo sapiens Q16539
Anti Tag CoIP
16751104
种属内
SUPT20H Q8NEM7 MAPK14 Homo sapiens Q16539
Y2H
16751104
种属内
SUPT20H Q8NEM7 ATXN1 Homo sapiens P54253
Y2H
16713569
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Spinocerebellar Ataxia, X-Linked 3

Scax3

X-Linked Spinocerebellar Ataxia 3

X-Linked Ataxia-Deafness Syndrome

X-Linked Spinocerebellar Ataxia Type 3

Ataxia-Deafness Syndrome, X-Linked

Spinocerebellar Ataxia X-Linked Type 3

Ataxia-Deafness Syndrome X-Linked

X-Linked Ataxia-Hearing Loss Syndrome

Spinocerebellar Ataxia, X-Linked, 3

Spinocerebellar Ataxia, X-Linked 4

Scax4

X-Linked Spinocerebellar Ataxia 4

X-Linked Ataxia-Dementia Syndrome

X-Linked Spinocerebellar Ataxia Type 4

Ataxia-Dementia Syndrome, X-Linked

Spinocerebellar Ataxia X-Linked Type 4

Ataxia-Dementia Syndrome X-Linked

Spinocerebellar Ataxia, X-Linked, 4

Macular Degeneration, Age-Related, 8

Age Related Macular Degeneration 8

ARMD8

Macular Degeneration, Age-Related, Type 8

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus SUPT20H VGNC VGNC:102339
Macaca mulatta SUPT20H VGNC VGNC:78182
Bos taurus SUPT20H VGNC VGNC:53835
Canis familiaris SUPT20H VGNC VGNC:59097
Mus musculus SUPT20H MGD MGI:1929651
Rattus norvegicus SUPT20H RGD RGD:1307812