BMP2K - BMP2 inducible kinase Gene

中文名称：BMP2 诱导激酶

种属: Homo sapiens

同用名: BIKE; HRIHFB2017

关于 BMP2K

功能概要

该基因是小鼠 BMP-2 诱导激酶的人类同系物。骨形态发生蛋白 (BMP) 在骨骼发育和模式形成中起着关键作用。在 BMP-2 诱导的分化过程中，小鼠基因的表达增加，基因产物是一种推定的含有核定位信号的丝氨酸/苏氨酸蛋白激酶。因此，这种人类同系物编码的蛋白质被认为是一种蛋白激酶，在减弱成骨细胞分化程序方面具有推定的调节作用。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]