2. Gene
  3. DOCK10 - dedicator of cytokinesis 10 Gene

DOCK10 - dedicator of cytokinesis 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胞质分裂因子 10

种属: Homo sapiens

同用名: ZIZ3; DRIP2; Nbla10300

基因 ID: 55619 | 基因类型: protein coding

关于 DOCK10

Cytogenetic location: 2q36.2 Genomic coordinates (GRCh38): 2:224,765,090-225,042,468 (from NCBI)

This gene has 18 transcripts (splice variants), 233 orthologues and 10 paralogues. Broad expression in spleen (RPKM 10.3), lymph node (RPKM 9.4) and 22 other tissues.

功能概要

该基因编码胞质分裂蛋白家族的一个成员。该家族的成员是 Rho GTP 酶的鸟苷核苷酸交换因子，由保守的 DOCK 同源区域的存在定义。编码的蛋白质属于 DOCK 蛋白的 D (或 Zizimin) 亚家族，它还包含一个 N 端 pleckstrin 同源结构域。已经描述了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2014 年 3 月]

This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]

DOCK10 基因产物(3)

mRNA Protein Name
NM_001290263.2 NP_001277192.1 dedicator of cytokinesis protein 10 isoform 2
NM_001363762.1 NP_001350691.1 dedicator of cytokinesis protein 10 isoform 3
NM_014689.3 NP_055504.2 dedicator of cytokinesis protein 10 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of cell migration IDA
IDA: 通过直接分析推断
18835169 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18499258 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18499258 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DOCK10 蛋白结构

DUF3398

DUF3398: Domain of unknown function (DUF3398) (61 - 153)

PH

PH: PH domain (183 - 288)

DOCK-C2

DOCK-C2: C2 domain in Dock180 and Zizimin proteins (667 - 860)

DHR-2

DHR-2: Dock homology region 2 (1966 - 2142)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2186 a.a.
蛋白主名 其他名称

dedicator of cytokinesis protein 10

dopamine receptor interacting protein 2

DOCK10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DOCK10 Q96BY6 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
种属内
DOCK10 Q96BY6 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
种属内
DOCK10 Q96BY6 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
种属内
DOCK10 Q96BY6 MAGEA11 Homo sapiens P43364
Y2H Array
32296183
种属内
DOCK10 Q96BY6 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency 40

Dock2 Deficiency

IMD40

Immunodeficiency, Type 40
Ayme-Gripp Syndrome

AYGRP

Cataracts, Congenital, With Sensorineural Deafness, Down Syndrome-Like Facial Appearance, Short Stature, And Mental Retardation

Aymé-Gripp Syndrome

Fine-Lubinsky Syndrome

Brachycephaly-Deafness-Cataract-Intellectual Disability Syndrome

Brachycephaly-Hearing Loss-Cataract-Intellectual Disability Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03922 DOCK10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus DOCK10 VGNC VGNC:28155
Canis familiaris DOCK10 VGNC VGNC:40044
Rattus norvegicus DOCK10 RGD RGD:1561963
Macaca mulatta DOCK10 VGNC VGNC:71888
Mus musculus DOCK10 MGD MGI:2146320
Felis catus DOCK10 VGNC VGNC:61570
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