PRKAB1 - protein kinase AMP-activated non-catalytic subunit beta 1 Gene

中文名称：蛋白激酶 AMP 激活的非催化亚基 β 1

种属: Homo sapiens

同用名: AMPK; HAMPKb

基因 ID: 5564 | 基因类型: protein coding

关于 PRKAB1

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:119,667,952-119,681,619 (from NCBI)

This gene has 10 transcripts (splice variants), 285 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 25.5), bone marrow (RPKM 15.9) and 25 other tissues.

功能概要

该基因编码的蛋白质是 AMP 活化蛋白激酶 (AMPK) 的调节亚基。 AMPK 是一种异源三聚体，由一个 α 催化亚基以及非催化 β 和 γ 亚基组成。 AMPK 是一种重要的能量感应酶，可监测细胞能量状态。响应细胞代谢应激，AMPK 被激活，从而使乙酰辅酶 A 羧化酶 (ACC) 和 β-羟基β-甲基戊二酰辅酶 A 还原酶 (HMGCR) 磷酸化和失活，这些酶是参与调节脂肪酸和胆固醇从头生物合成的关键酶.该亚基可能是 AMPK 活性的正调节因子。该亚基的豆蔻酰化和磷酸化已被证明会影响 AMPK 的酶活性和细胞定位。该亚基也可作为衔接分子介导 AMPK 复合物的结合。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing Enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates Acetyl-CoA Carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key Enzymes involved in regulating de novo biosynthesis of fatty acid and Cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the Enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]

PRKAB1 基因产物(1)

mRNA	Protein	Name
NM_006253.5	NP_006244.2	5'-AMP-activated protein kinase subunit beta-1

PRKAB1 蛋白结构

AMPKBI

0
100
200
270 a.a.

蛋白主名

其他名称

5'-AMP-activated protein kinase subunit beta-1

5'-AMP-activated protein kinase beta-1 subunit

PRKAB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PRKAB1	Q9Y478	PRKAA1	Homo sapiens	Q13131	Anti Tag CoIP	33961781
种属内	PRKAB1	Q9Y478	PRKAA1	Homo sapiens	Q13131	Anti Tag CoIP	20562859
种属内	PRKAB1	Q9Y478	PRKAA1	Homo sapiens	Q13131	Anti Bait CoIP	22363791
种属内	PRKAB1	Q9Y478	PRKAG1	Homo sapiens	P54619	Y2H Array	21988832
种属内	PRKAB1	Q9Y478	PRKAG1	Homo sapiens	P54619	Anti Tag CoIP	20562859
种属内	PRKAB1	Q9Y478	PRKAG1	Homo sapiens	P54619	Anti Tag CoIP	33961781
种属内	PRKAB1	Q9Y478	PRKAG1	Homo sapiens	P54619	Anti Bait CoIP	22363791
种属内	PRKAB1	Q9Y478	PRKAA2	Homo sapiens	P54646	Anti Tag CoIP	20562859
种属内	PRKAB1	Q9Y478	PRKAA2	Homo sapiens	P54646	Anti Tag CoIP	33961781
种属内	PRKAB1	Q9Y478	PRKAA2	Homo sapiens	P54646	Anti Tag CoIP	28514442
种属内	PRKAB1	Q9Y478	GRB2	Homo sapiens	P62993	Y2H	18624398
种属内	PRKAB1	Q9Y478	GRB2	Homo sapiens	P62993	Anti Tag CoIP	18624398
种属间	PRKAB1	Q9Y478	Cidea	Mus musculus	O70302	Anti Tag CoIP	18480843
种属间	PRKAB1	Q9Y478	Cidea	Mus musculus	O70302	Anti Bait CoIP	18480843
种属间	PRKAB1	Q9Y478	Cidea	Mus musculus	O70302	IF	18480843
种属内	PRKAB1	Q9Y478	ULK1	Homo sapiens	O75385	Anti Tag CoIP	21072212

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PRKAB1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76141	AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST)	P54619 (M1-P331)&Q9Y478 (M1-I270)&Q13131 (M1-Q559)	≥95%
HY-P76142	AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (sf9, His-GST)	P54619 (M1-P331)&Q9Y478 (M1-I270)&P54646 (M1-R552)	≥95%

关联疾病

疾病名称

别名

Krabbe Disease

Globoid Cell Leukodystrophy	Galactosylceramide Beta-Galactosidase Deficiency
Galc Deficiency	Galactocerebrosidase Deficiency
GLD	Globoid Cell Leukoencephalopathy
Diffuse Globoid Body Sclerosis	Gcl
Leukodystrophy, Globoid Cell	Krabbe'S Leukodystrophy
Krabbe Leukodystrophy	KRB
Beta Galactocerebrosidase Deficiency	Krabbe'S Disease
Galactosylceramidase Deficiency Disease	Galactosylceramide Lipidosis
Galactosylcerebrosidase Deficiency	Galactosylsphingosine Lipidosis
Psychosine Lipidosis	Galactosylceramidase Deficiency
Infantile Globoid Cell Leukodystrophy	Krabbe Brain Sclerosis

Hyperglycemia

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Kidney Cancer

Renal Cancer	Renal Carcinoma
Kidney Neoplasm	Malignant Neoplasm Of Kidney Except Pelvis
Malignant Tumour Of Kidney	Kidney Neoplasms
Cancer, Kidney	Cancer, Renal
Malignant Neoplasm Of Kidney	Renal Cell Carcinoma

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11102	PRKAB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	PRKAB1	VGNC	VGNC:44969
Mus musculus	PRKAB1	MGD	MGI:1336167
Bos taurus	PRKAB1	VGNC	VGNC:33319
Rattus norvegicus	PRKAB1	RGD	RGD:71057
Macaca mulatta	PRKAB1	VGNC	VGNC:76401
Felis catus	PRKAB1	VGNC	VGNC:69047
Others	PRKAB1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRKAB1 - protein kinase AMP-activated non-catalytic subunit beta 1 Gene

关于 PRKAB1

功能概要

PRKAB1 基因产物(1)

PRKAB1 蛋白结构

PRKAB1 蛋白互作信息

重组 PRKAB1 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

PRKAB1 - protein kinase AMP-activated non-catalytic subunit beta 1 Gene

关于 PRKAB1

功能概要

PRKAB1 基因产物(1)

PRKAB1 蛋白结构

PRKAB1 蛋白互作信息

重组 PRKAB1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z