1. Gene
  2. Cidea - cell death-inducing DNA fragmentation factor, alpha subunit-like effector A Gene

Cidea - cell death-inducing DNA fragmentation factor, alpha subunit-like effector A Gene

种属: Mus musculus

基因 ID: 12683 | 基因类型: protein coding

关于 Cidea

功能概要

Enables protein homodimerization activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of sequestering of triglyceride. Acts upstream of or within lipid metabolic process and response to stilbenoid. Located in mitochondrial envelope and nucleus. Colocalizes with lipid droplet. Is expressed in brown fat. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CIDEA (cell death inducing DFFA like effector a). [provided by Alliance of Genome Resources, Apr 2022]

Cidea 基因产物(1)

mRNA Protein Name
NM_007702.2 NP_031728.2 cell death activator CIDE-A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables lipid transfer activity IDA
IDA: 通过直接分析推断
22144693 MGI
enables phosphatidic acid binding IDA
IDA: 通过直接分析推断
26609809 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12910269 MGI
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
17080483 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to cold IDA
IDA: 通过直接分析推断
28763438 MGI
involved in lipid droplet fusion IDA
IDA: 通过直接分析推断
22144693 MGI
acts upstream of or within lipid metabolic process IMP
IMP: 通过突变表型推断
12910269 MGI
involved in lipid storage IDA
IDA: 通过直接分析推断
22144693 MGI
involved in lipid storage IMP
IMP: 通过突变表型推断
12910269 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
12910269 MGI
involved in negative regulation of execution phase of apoptosis IDA
IDA: 通过直接分析推断
17080483 MGI
involved in negative regulation of lipid catabolic process IMP
IMP: 通过突变表型推断
12910269 MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
17080483 MGI
involved in positive regulation of sequestering of triglyceride IDA
IDA: 通过直接分析推断
18509062 MGI
involved in regulation of apoptotic DNA fragmentation IDA
IDA: 通过直接分析推断
9564035 MGI
involved in response to stilbenoid IEP
IEP: 通过表达模式推断
17086191 MGI
involved in temperature homeostasis IMP
IMP: 通过突变表型推断
12910269 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17080483 MGI
colocalizes with lipid droplet IDA
IDA: 通过直接分析推断
18509062 MGI
is active in lipid droplet IDA
IDA: 通过直接分析推断
20810722 MGI
located in mitochondrial envelope IDA
IDA: 通过直接分析推断
12910269 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
12910269 MGI
located in nucleus IDA
IDA: 通过直接分析推断
17080483 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

cell death activator CIDE-A

cell death-inducing DFFA-like effector A

Cidea 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Cidea O70302 PRKAB1 Homo sapiens Q9Y478
IF
18480843
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cidea NCBI NCBI:1149