DDX27 - DEAD-box helicase 27 Gene

中文名称：死盒解旋酶 27

种属: Homo sapiens

同用名: DRS1; RHLP; Drs1p; PP3241; HSPC259; dJ686N3.1

关于 DDX27

功能概要

以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。它们涉及许多涉及 RNA 二级结构改变的细胞过程，例如翻译起始、核和线粒体剪接以及核糖体和剪接体组装。根据它们的分布模式，该家族的一些成员被认为参与了胚胎发生、精子发生以及细胞生长和分裂。该基因编码参与 5.8S 和 28S 核糖体 RNA 加工的 DEAD 盒蛋白。更具体地说，编码的蛋白质定位于核仁，在那里它与 PeBoW 复合物相互作用，以确保正确形成 47S rRNA 的 3' 端。[RefSeq 提供，2017 年 1 月]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]