YEATS2 - YEATS domain containing 2 Gene

中文名称：含 YEATS 结构域 2

种属: Homo sapiens

同用名: FAME4

基因 ID: 55689 | 基因类型: protein coding

关于 YEATS2

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:183,697,797-183,812,624 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 7.4), brain (RPKM 7.1) and 25 other tissues.

功能概要

摘要：该基因编码的蛋白质是 ATAC 复合物的支架亚基，该复合物是一种对组蛋白 H3 和 H4 具有乙酰转移酶活性的复合物。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2017 年 5 月]

Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

YEATS2 基因产物(4)

mRNA	Protein	Name
NM_001351369.2	NP_001338298.1	YEATS domain-containing protein 2 isoform 3
NM_001351370.2	NP_001338299.1	YEATS domain-containing protein 2 isoform 1
NM_001351371.2	NP_001338300.1	YEATS domain-containing protein 2 isoform 2
NM_018023.5	NP_060493.3	YEATS domain-containing protein 2 isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables TBP-class protein binding	IPI IPI: 通过物理相互作用推断	18838386	GOA
enables histone binding	IDA IDA: 通过直接分析推断	27103431	GOA
enables histone reader activity	IDA IDA: 通过直接分析推断	27103431	GOA
enables modification-dependent protein binding	IDA IDA: 通过直接分析推断	27103431	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18838386	GOA
enables transcription corepressor activity	IDA IDA: 通过直接分析推断	18838386	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	18838386	GOA
involved in regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	19936620	GOA
involved in regulation of cell cycle	IMP IMP: 通过突变表型推断	19103755	GOA
involved in regulation of cell division	IDA IDA: 通过直接分析推断	20562830	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	22055187	GOA
involved in regulation of tubulin deacetylation	IMP IMP: 通过突变表型推断	20562830	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of ATAC complex	IDA IDA: 通过直接分析推断	18838386	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

YEATS2 蛋白结构

YEATS

0
300
600
900
1200
1422 a.a.

蛋白主名

其他名称

YEATS domain-containing protein 2

关联疾病

疾病名称

别名

Epilepsy, Familial Adult Myoclonic, 4

FAME4	Fcmte4
Cortical Myoclonic Tremor With Epilepsy, Familial, 4	Familial Adult Myoclonic Epilepsy 4
Epilepsy, Myoclonic, Familial Adult, 4	Familial Cortical Myoclonic Tremor And Epilepsy 4
Epilepsy, Myoclonic, Familial Adult, Type 4

Familial Adult Myoclonic Epilepsy

Benign Adult Familial Myoclonus Epilepsy	Bafme
Benign Adult Familial Myoclonic Epilepsy	Fame
Familial Cortical Myoclonic Tremor And Epilepsy	Fcmte
Adcme	Autosomal Dominant Cortical Myoclonus And Epilepsy
Fam	Epilepsy, Myoclonic, Familial Adult
Epilepsy, Myoclonic, Benign Adult Familial, Type 2

Epilepsy, Familial Adult Myoclonic, 7

FAME7	Bafme7
Fcmte7	Benign Adult Familial Myoclonic Epilepsy 7
Cortical Myoclonic Tremor With Epilepsy, Familial, 7	Familial Adult Myoclonic Epilepsy 7
Familial Cortical Myoclonic Tremor And Epilepsy 7	Benign Adult Familial Myoclonic Epilepsy 27
Epilepsy, Myoclonic, Familial Adult, Type 7

Epilepsy, Familial Adult Myoclonic, 1

FAME1	Benign Adult Familial Myoclonic Epilepsy 1
Bafme1	Fcmte1
Cortical Myoclonic Tremor With Epilepsy, Familial, 1	Familial Adult Myoclonic Epilepsy 1
Familial Cortical Myoclonic Tremor And Epilepsy 1	Epilepsy, Myoclonic, Familial Adult, Type 1

Epilepsy, Familial Adult Myoclonic, 3

FAME3	Fcmte3
Cortical Myoclonic Tremor With Epilepsy, Familial, 3	Familial Adult Myoclonic Epilepsy 3
Familial Cortical Myoclonic Tremor And Epilepsy 3	Epilepsy, Myoclonic, Familial Adult, Type 3

Epilepsy, Familial Adult Myoclonic, 2

FAME2	Benign Adult Familial Myoclonic Epilepsy 2
Bafme2	Fcmte2
Adcme	Cortical Myoclonic Tremor With Epilepsy, Familial, 2
Cortical Myoclonus And Epilepsy, Autosomal Dominant	Familial Adult Myoclonic Epilepsy 2
Epilepsy, Myoclonic, Benign Adult Familial, Type 2	Autosomal Dominant Cortical Myoclonus And Epilepsy
Familial Cortical Myoclonic Tremor And Epilepsy 2	Epilepsy, Myoclonic, Familial Adult, Type 2

Epilepsy, Familial Adult Myoclonic, 6

FAME6	Benign Adult Familial Myoclonic Epilepsy 6
Bafme6	Fcmte6
Cortical Myoclonic Tremor With Epilepsy, Familial, 6	Familial Adult Myoclonic Epilepsy 6
Familial Cortical Myoclonic Tremor And Epilepsy 6	Epilepsy, Myoclonic, Familial Adult, Type 6

Macular Dystrophy, Patterned, 3

Martinique Crinkled Retinal Pigment Epitheliopathy	Patterned Macular Dystrophy 3
MDPT3	Mcrpe

Periosteal Chondrosarcoma

Juxtacortical Chondrosarcoma

Mild Cognitive Impairment

Adolescence-Adult Electroclinical Syndrome

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Spondyloepiphyseal Dysplasia Congenita

SEDC	Sed Congenita
Spondyloepiphyseal Dysplasia, Congenital Type	Late Spondyloepiphyseal Dysplasia
Sed, Congenital Type	Congenital Spondyloepiphyseal Dysplasia
Spranger-Wiedemann Disease	Spondyloepiphyseal Dysplasia Congenital Type
Dysplasia, Spondyloepiphyseal, Congenita	Spondyloepiphyseal Dysplasia, Congenita
Spondyloepiphyseal Dysplasia Tarda, X-Linked

Heinz Body Anemias

Heinz Body Anemia	Heinz Body Anemias, Alpha-
HEIBAN	Anemia, Heinz Body
Acquired Heinz Body Anemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15920	YEATS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	YEATS2	VGNC	VGNC:48482
Macaca mulatta	YEATS2	VGNC	VGNC:79502
Mus musculus	YEATS2	MGD	MGI:2447762
Rattus norvegicus	YEATS2	RGD	RGD:1566176
Felis catus	YEATS2	VGNC	VGNC:67134
Bos taurus	YEATS2	VGNC	VGNC:37020

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

YEATS2 - YEATS domain containing 2 Gene

关于 YEATS2

功能概要

YEATS2 基因产物(4)

YEATS2 蛋白结构

关联疾病

直系同源

热门区域

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YEATS2 - YEATS domain containing 2 Gene

关于 YEATS2

功能概要

YEATS2 基因产物(4)

YEATS2 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z