FAR2 - fatty acyl-CoA reductase 2 Gene

中文名称：脂酰辅酶 A 还原酶 2

种属: Homo sapiens

同用名: MLSTD1; SDR10E2; HEL-S-81

基因 ID: 55711 | 基因类型: protein coding

关于 FAR2

Cytogenetic location: 12p11.22 Genomic coordinates (GRCh38): 12:29,149,278-29,335,616 (from NCBI)

This gene has 25 transcripts (splice variants), 251 orthologues and 1 paralogue. Broad expression in colon (RPKM 8.7), small intestine (RPKM 5.0) and 22 other tissues.

功能概要

该基因属于短链脱氢酶/还原酶超家族。它编码参与蜡生物合成第一步的还原酶，其中脂肪酸被转化为脂肪醇。编码的过氧化物酶体蛋白利用 16 或 18 个碳的饱和脂肪酸作为首选底物。已观察到该基因的可变剪接转录物变体。已在 2、14 和 22 号染色体上鉴定出相关的假基因。[RefSeq 提供，2012 年 11 月]

This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase Enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]

FAR2 基因产物(3)

mRNA	Protein	Name
NM_001271783.2	NP_001258712.1	fatty acyl-CoA reductase 2 isoform 1
NM_001271784.2	NP_001258713.1	fatty acyl-CoA reductase 2 isoform 2
NM_018099.5	NP_060569.3	fatty acyl-CoA reductase 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity	IDA IDA: 通过直接分析推断	15220348	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in long-chain fatty-acyl-CoA metabolic process	IDA IDA: 通过直接分析推断	15220348	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in peroxisomal membrane	IDA IDA: 通过直接分析推断	24108123	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FAR2 蛋白结构

NAD_binding_4

Sterile

0
100
200
300
400
515 a.a.

蛋白主名

其他名称

fatty acyl-CoA reductase 2

epididymis secretory protein Li 81

关联疾病

疾病名称

别名

Retinitis Pigmentosa 27

RP27	Retinal Degeneration, Autosomal Recessive, Clumped Pigment Type
Retinal Degeneration Autosomal Recessive Clumped Pigment Type	RDCP
Clumped Pigmentary Retinal Degeneration	Retinitis Pigmentosa, Type 27

Necatoriasis

Miner'S Anaemia	Negro Cachexia
Dochmiasis	Ground Itch Disease
Brickmaker'S Chlorosis	Coolie Itch Anaemia
Cachexia Aquosa	Dew Itch Anaemia
Brickmaker'S Anaemia	Tunnel Worker'S Anaemia
Egyptian Anaemia	Tunnel Worker'S Disease
Miner'S Cachexia	Greisinger Disease
Tropical Chlorosis	Egyptian Chlorosis
Tunnel Anaemia	Dochmiosis
Necatorosis	African Cachexia
Water Itch Anaemia	Infection Due To Necator Americanus
St Gotthard Disease	Gotthard Tunnel Disease

Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders	Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum
Disorders Of Peroxisome Biogenesis	Zellweger Spectrum
Zellweger Syndrome Spectrum	Peroxisomal Biogenesis Disorders
Pbd, Zss	Pbd-Zsd
Pbd-Zss	Pbd-Zellweger Spectrum Disorder
Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum	Peroxisome Biogenesis Disorder
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorders
Zellweger Spectrum Disorder	Hyperpipecolic Acidaemia

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder	Infantile Refsum Disease
Infantile Phytanic Acid Storage Disease	PBD1B
Refsum Disease, Infantile	Adrenoleukodystrophy, Autosomal Neonatal
Ird	Mild Pbd-Zsd
Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder	Pbd-Zsd
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Autosomal Neonatal Adrenoleukodystrophy	Refsum Disease Infantile
Peroxisome Biogenesis Disorders	Peroxisome Biogenesis Disorder, Type 1b

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04745	FAR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04748	FARS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	FAR2	VGNC	VGNC:28864
Felis catus	FAR2	VGNC	VGNC:62148
Mus musculus	FAR2	MGD	MGI:2687035
Rattus norvegicus	FAR2	RGD	RGD:1565966
Macaca mulatta	FAR2	VGNC	VGNC:81403
Canis familiaris	FAR2	VGNC	VGNC:40729

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FAR2 - fatty acyl-CoA reductase 2 Gene

关于 FAR2

功能概要

FAR2 基因产物(3)

FAR2 蛋白结构

关联疾病

直系同源

热门区域

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FAR2 - fatty acyl-CoA reductase 2 Gene

关于 FAR2

功能概要

FAR2 基因产物(3)

FAR2 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z