EXOC2 - exocyst complex component 2 Gene

中文名称：exocyst 复杂组件 2

种属: Homo sapiens

同用名: SEC5; Sec5p; SEC5L1; NEDFACH

关于 EXOC2

功能概要

由该基因编码的蛋白质是胞吐复合物的一个组成部分，胞吐复合物是一种多蛋白复合物，对于胞吐囊泡极化靶向质膜上的特定停靠位点至关重要。尽管在酵母中得到了最好的表征，但已证明 exocyst 复合体的组成蛋白和功能在高等真核生物中高度保守。发现 exocyst 复合物的至少八种成分 (包括这种蛋白质) 与肌动蛋白细胞骨架重塑和囊泡转运机制相互作用。这种相互作用已被证明可以介导成纤维细胞中丝状伪足的形成。这种蛋白质已被证明与 GTP 酶的 Ral 亚家族相互作用，从而通过将囊泡束缚在质膜上来介导胞吐作用。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 7 月]

The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]