RNF130 - ring finger protein 130 Gene

中文名称：无名指蛋白 130

种属: Homo sapiens

同用名: GP; G1RP; G1RZFP; GOLIATH

关于 RNF130

功能概要

该基因编码的蛋白质包含一个环指基序，类似于 g1，一种在中胚层中表达并参与胚胎发育的果蝇锌指蛋白。在 IL3 剥夺后，发现小鼠对应物的表达在成髓细胞中上调，表明该基因可能调节生长因子戒断诱导的骨髓前体细胞凋亡。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced Apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]