SELENOS - selenoprotein S Gene

中文名称：硒蛋白 S

种属: Homo sapiens

同用名: SELS; VIMP; ADO15; SBBI8; SEPS1; AD-015

关于 SELENOS

功能概要

该基因编码一种位于内质网 (ER) 中的跨膜蛋白。它参与 ER 中错误折叠蛋白质的降解过程，也可能在炎症控制中发挥作用。这种蛋白质是一种硒蛋白，含有稀有氨基酸硒代半胱氨酸 (Sec) 。 Sec 由 UGA 密码子编码，通常表示翻译终止。硒蛋白 mRNA 的 3' UTR 包含一个保守的茎环结构，称为 Sec 插入序列 (SECIS) 元件，这是将 UGA 识别为 Sec 密码子而不是终止信号所必需的。该 mRNA 的 3' UTR 中的两个额外的系统发育保守的茎环结构 (茎环 1 和茎环 2) 已被证明可作为 Sec 插入的调节剂。已针对该基因描述了一种可变剪接的转录变体，它缺少 SECIS 元件并编码包含较短同种型的非 Sec (PMID:23614019) 。[RefSeq 提供，2017 年 7 月]

This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]