PKN2 - protein kinase N2 Gene

中文名称：蛋白激酶 N2

种属: Homo sapiens

同用名: PAK2; PRK2; STK7; Pak-2; PRKCL2; PRO2042

基因 ID: 5586 | 基因类型: protein coding

关于 PKN2

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:88,684,273-88,836,255 (from NCBI)

This gene has 6 transcripts (splice variants), 287 orthologues and 9 paralogues. Ubiquitous expression in ovary (RPKM 11.1), duodenum (RPKM 10.9) and 25 other tissues.

功能概要

启用 RNA 聚合酶结合活性；组蛋白脱乙酰酶结合活性；和蛋白丝氨酸/苏氨酸激酶活性。涉及多个过程，包括顶端连接组装；细胞周期的正调节；和病毒基因组复制的正调控。位于多个细胞成分中，包括卵裂沟；细胞骨架；和中体。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase binding activity; histone deacetylase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including apical junction assembly; positive regulation of cell cycle; and positive regulation of viral genome replication. Located in several cellular components, including cleavage furrow; cytoskeleton; and midbody. [provided by Alliance of Genome Resources, Apr 2022]

PKN2 基因产物(4)

mRNA	Protein	Name
NM_001320707.2	NP_001307636.1	serine/threonine-protein kinase N2 isoform 2
NM_001320708.2	NP_001307637.1	serine/threonine-protein kinase N2 isoform 3
NM_001320709.2	NP_001307638.1	serine/threonine-protein kinase N2 isoform 4
NM_006256.4	NP_006247.1	serine/threonine-protein kinase N2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase binding	IPI IPI: 通过物理相互作用推断	15364941	GOA
enables histone deacetylase binding	IDA IDA: 通过直接分析推断	20188095	GOA
enables kinase activity	IDA IDA: 通过直接分析推断	15364941	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10026169	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	20188095	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in apical junction assembly	IMP IMP: 通过突变表型推断	20974804	GOA
involved in epithelial cell migration	IDA IDA: 通过直接分析推断	21754995	GOA
involved in positive regulation of cytokinesis	IMP IMP: 通过突变表型推断	17332740	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: 通过突变表型推断	17332740	GOA
involved in positive regulation of viral genome replication	IMP IMP: 通过突变表型推断	15364941	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	17332740	GOA
involved in regulation of cell motility	IMP IMP: 通过突变表型推断	21754995	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical junction complex	IDA IDA: 通过直接分析推断	20974804	GOA
located in cleavage furrow	IDA IDA: 通过直接分析推断	17332740	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	17332740	GOA
located in lamellipodium	IDA IDA: 通过直接分析推断	11356191	GOA
located in midbody	IDA IDA: 通过直接分析推断	17332740	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11356191	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	15364941	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	23223530	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PKN2 蛋白结构

HR1

Pkinase

Pkinase_C

0
200
400
600
800
984 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase N2

PKN gamma

PKN2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PKN2	Q16513	CETN2	Homo sapiens	P41208	Anti Tag CoIP	35271311
Intra	PKN2	Q16513	PDK1	Homo sapiens	Q15118	Protein Kinase Assay	17110931
Cross	PKN2	Q16513	O92972-PRO_0000278753	Hepatitis C virus	O92972-PRO_0000278753	ELISA	15364941
Cross	PKN2	Q16513	O92972-PRO_0000278753	Hepatitis C virus	O92972-PRO_0000278753	Anti Bait CoIP	15364941

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome	Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome
Syndactyly With Renal And Anogenital Malformations	STAR
Syndactyly, Telecanthus, Anogenital And Renal Malformations	Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Bubonic Plague

Black Death	Plague, Bubonic
Plague, Septicemic	Pestis Bubonica

Mevalonic Aciduria

Mevalonate Kinase Deficiency	Mevalonicaciduria
Hyperimmunoglobulin D With Periodic Fever	MEVA
Complete Mevalonate Kinase Deficiency	Mva
Hyperimmunoglobulinemia D	Hyper Igd Syndrome
Periodic Fever, Dutch Type	Mkd
Aciduria, Mevalonic	Deficiency Of Mevalonate Kinase

Plague

Yersiniosis	Yersinia Infections
Infection By Yersinia Pestis	Pasteurella Pestis Infection
Pestilential Fever	Yersinia Pestis Infection

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-145899	PKN1/2-IN-1	Inhibitor	98.48%	否
HY-RS10607	PKN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	PKN2	VGNC	VGNC:32946
Macaca mulatta	PKN2	VGNC	VGNC:76015
Canis familiaris	PKN2	VGNC	VGNC:44612
Felis catus	PKN2	VGNC	VGNC:69064
Rattus norvegicus	PKN2	RGD	RGD:620146
Mus musculus	PKN2	MGD	MGI:109211
Others	PKN2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PKN2 - protein kinase N2 Gene

关于 PKN2

功能概要

PKN2 基因产物(4)

PKN2 蛋白结构

PKN2 蛋白互作信息

关联疾病

直系同源

热门区域

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PKN2 - protein kinase N2 Gene

关于 PKN2

功能概要

PKN2 基因产物(4)

PKN2 蛋白结构

PKN2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z