PBK - PDZ binding kinase Gene

中文名称：PDZ 结合激酶

种属: Homo sapiens

同用名: SPK; CT84; TOPK; HEL164; Nori-3

关于 PBK

功能概要

该基因编码与双特异性丝裂原活化蛋白激酶激酶 (MAPKK) 家族相关的丝氨酸/苏氨酸蛋白激酶。有证据表明，有丝分裂磷酸化是其催化活性所必需的。所编码的蛋白质可能参与淋巴样细胞的激活并支持睾丸功能，在精子发生过程中可能发挥作用。该基因的过度表达与肿瘤发生有关。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]