2. Gene
  3. UNC45A - unc-45 myosin chaperone A Gene

UNC45A - unc-45 myosin chaperone A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：unc-45 肌球蛋白伴侣 A

种属: Homo sapiens

同用名: OOHE; SMAP1; SMAP-1; GCUNC45; UNC-45A; GC-UNC45; GCUNC-45; IRO039700

基因 ID: 55898 | 基因类型: protein coding

关于 UNC45A

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,930,180-90,954,093 (from NCBI)

This gene has 17 transcripts (splice variants), 199 orthologues, 18 paralogues and is associated with 2 phenotypes. Ubiquitous expression in prostate (RPKM 14.4), skin (RPKM 14.0) and 25 other tissues.

功能概要

该基因编码孕激素受体/热休克蛋白 90 伴侣复合物的调节成分，其在孕激素受体的组装和折叠中发挥作用。编码的蛋白质被认为对于正常细胞增殖和肌肉细胞发育过程中肌球蛋白的积累是必不可少的。[RefSeq 提供，2018 年 9 月]

This gene encodes a regulatory component of the Progesterone Receptor/heat shock protein 90 chaperoning complex, which functions in the assembly and folding of the Progesterone Receptor. The encoded protein is thought to be essential for normal cell proliferation, and for the accumulation of Myosin during development of muscle cells. [provided by RefSeq, Sep 2018]

UNC45A 基因产物(5)

mRNA Protein Name
NM_001039675.2 NP_001034764.1 protein unc-45 homolog A isoform 3
NM_001323619.1 NP_001310548.1 protein unc-45 homolog A isoform 2
NM_001323620.2 NP_001310549.1 protein unc-45 homolog A isoform 4
NM_001323621.2 NP_001310550.1 protein unc-45 homolog A isoform 3
NM_018671.5 NP_061141.2 protein unc-45 homolog A isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25036637 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UNC45A 蛋白结构

TPR_11

TPR_11: TPR repeat (22 - 88)

TPR_2

TPR_2: Tetratricopeptide repeat (93 - 125)

UNC45-central

UNC45-central: Myosin-binding striated muscle assembly central (289 - 505)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 944 a.a.
蛋白主名 其他名称

protein unc-45 homolog A

general cell UNC45

关联疾病

疾病名称 别名
Osteootohepatoenteric Syndrome

OOHE

O2he
Congenital Diarrhea
Inflammatory Bowel Disease 27

IBD27
Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin
Cholestasis

Obstruction Of Bile Duct

Bile Duct Obstruction

Bile Occlusion

Extrahepatic Biliary Obstruction

Extrahepatic Bile Duct Obstruction

Bile Stasis

Biliary Stasis

Obstructive Hyperbilirubinemia

Obstructed Jaundice

Bile Duct Obstructed

Bile Ductal Obstruction

Biliary Duct Obstruction

Obstructed Bile Ductal

Obstructed Biliary Duct

Obstructed Biliary Ductal

Jaundice Regurgitation

Obstructive Jaundice

Cholestatic Jaundice

Cholestatic Jaundice Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15468 UNC45A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus UNC45A RGD RGD:1305357
Felis catus UNC45A VGNC VGNC:66825
Bos taurus UNC45A VGNC VGNC:36667
Canis familiaris UNC45A VGNC VGNC:48137
Mus musculus UNC45A MGD MGI:2142246
Macaca mulatta UNC45A VGNC VGNC:79858
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