2. Gene
  3. RCC2 - regulator of chromosome condensation 2 Gene

RCC2 - regulator of chromosome condensation 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：染色体凝缩调控因子 2

种属: Homo sapiens

同用名: TD-60

基因 ID: 55920 | 基因类型: protein coding

关于 RCC2

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,406,760-17,439,677 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 214 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 29.5), skin (RPKM 28.3) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种鸟嘌呤交换因子，它在 RalA (一种小 GTP 酶) 上具有活性。编码的蛋白质和 RalA 对于早期有丝分裂中正确的着丝粒-微管功能都是必不可少的。这种蛋白质已被证明是结直肠癌的生物标志物。[RefSeq 提供，2016 年 10 月]

The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early mitosis. This protein has been shown to be a biomarker for colorectal Cancer. [provided by RefSeq, Oct 2016]

RCC2 基因产物(2)

mRNA Protein Name
NM_001136204.3 NP_001129676.1 protein RCC2
NM_018715.4 NP_061185.1 protein RCC2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables microtubule binding IMP
IMP: 通过突变表型推断
12919680 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22282019 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
25074804 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
25074804 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
12919680 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromosome passenger complex localization to kinetochore IMP
IMP: 通过突变表型推断
12919680 GOA
involved in focal adhesion assembly IDA
IDA: 通过直接分析推断
19738201 GOA
involved in integrin-mediated signaling pathway IDA
IDA: 通过直接分析推断
19738201 GOA
involved in negative regulation of GTPase activity IMP
IMP: 通过突变表型推断
25074804 GOA
involved in positive regulation of G2/M transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
12919680 GOA
involved in positive regulation of attachment of spindle microtubules to kinetochore IMP
IMP: 通过突变表型推断
12919680 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome, centromeric core domain IDA
IDA: 通过直接分析推断
12919680 GOA
colocalizes with membrane IDA
IDA: 通过直接分析推断
25074804 GOA
located in midbody IDA
IDA: 通过直接分析推断
12919680 GOA
located in mitotic spindle midzone IDA
IDA: 通过直接分析推断
12919680 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RCC2 蛋白结构

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (168 - 217)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (221 - 268)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (272 - 345)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (350 - 399)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 522 a.a.
蛋白主名 其他名称

protein RCC2

RCC1-like protein TD-60

关联疾病

疾病名称 别名
Atrial Septal Defect 2

ASD2

Atrial Heart Septal Defect 2

Atrial Septal Defect-2

Asd Ii

Septal Defect, Atrial, Type 2
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-139782 SKLB325 99.23% 否
HY-RS11784 RCC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus RCC2 VGNC VGNC:33827
Macaca mulatta RCC2 VGNC VGNC:100054
Canis familiaris RCC2 VGNC VGNC:45441
Felis catus RCC2 VGNC VGNC:64546
Mus musculus RCC2 MGD MGI:1919784
Rattus norvegicus RCC2 RGD RGD:1309986
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