2. Gene
  3. AJAP1 - adherens junctions associated protein 1 Gene

AJAP1 - adherens junctions associated protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：粘附连接相关蛋白 1

种属: Homo sapiens

同用名: MOT8; SHREW1; SHREW-1

基因 ID: 55966 | 基因类型: protein coding

关于 AJAP1

Cytogenetic location: 1p36.32 Genomic coordinates (GRCh38): 1:4,654,609-4,792,534 (from NCBI)

This gene has 3 transcripts (splice variants) and 195 orthologues. Biased expression in brain (RPKM 4.3), ovary (RPKM 2.3) and 5 other tissues.

功能概要

启用 β-连环蛋白结合活性。参与细胞-基质粘附的负调控；伤口愈合的负调节；极化上皮细胞分化的调控。位于多个细胞成分中，包括粘附连接；基底外侧质膜；和细胞间接触区。是质膜的跨越组分。 [由基因组资源联盟提供，2022 年 4 月]

Enables beta-catenin binding activity. Involved in negative regulation of cell-matrix adhesion; negative regulation of wound healing; and regulation of polarized epithelial cell differentiation. Located in several cellular components, including adherens junction; basolateral plasma membrane; and cell-cell contact zone. Is spanning component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

AJAP1 基因产物(2)

mRNA Protein Name
NM_001042478.2 NP_001035943.1 adherens junction-associated protein 1 precursor
NM_018836.4 NP_061324.1 adherens junction-associated protein 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-catenin binding IPI
IPI: 通过物理相互作用推断
14595118 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17267690 GOA
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
14595118 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cell-matrix adhesion IDA
IDA: 通过直接分析推断
16410724 GOA
involved in negative regulation of wound healing IDA
IDA: 通过直接分析推断
16410724 GOA
involved in regulation of polarized epithelial cell differentiation IDA
IDA: 通过直接分析推断
14595118 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IDA
IDA: 通过直接分析推断
14595118 GOA
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
16707570 GOA
located in cell surface IDA
IDA: 通过直接分析推断
14595118 GOA
located in cell-cell contact zone IDA
IDA: 通过直接分析推断
14595118 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
14595118 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
14595118 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AJAP1 蛋白结构

AJAP1_PANP_C

AJAP1_PANP_C: AJAP1/PANP C-terminus (181 - 388)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
蛋白主名 其他名称

adherens junction-associated protein 1

membrane protein shrew-1

关联疾病

疾病名称 别名
Dental Caries

Dental Caries Extending Into Pulp

Dental Caries Of Smooth Surface

Dental Caries Pit And Fissure

Smooth Surface Dental Caries

Dental Decay

Carious Teeth

Dental Cavity

Saprodontia

Teeth Decayed

Tooth Caries

Tooth Decay
Osteogenesis Imperfecta, Type I

Osteogenesis Imperfecta Type I

OI1

Oi, Type I

Osteogenesis Imperfecta Tarda

Osteogenesis Imperfecta With Blue Sclerae

Osteogenesis Imperfecta Type 1

Adair-Dighton Syndrome

Mild Osteogenesis Imperfecta

Non-Deforming Osteogenesis Imperfecta

Oi Type 1

Van Der Hoeve Syndrome

Classic Non-Deforming Oi With Blue Sclerae

Osteogenesis Imperfecta 1

Oi-I

Osteopenic Non-Fracture Syndrome

Osteogenesis Imperfecta, Mild

Osteogenesis Imperfecta

Lobstein'S Disease
Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome

Deletion 1p36

Monosomy 1p36

Subtelomeric 1p36 Deletion

Monosomy 1p36 Syndrome

Distal Monosomy 1p36

Del(1)(P36)

Deletion 1pter

Monosomy 1pter
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00502 AJAP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta AJAP1 VGNC VGNC:106318
Rattus norvegicus AJAP1 RGD RGD:1590138
Bos taurus AJAP1 VGNC VGNC:25768
Canis familiaris AJAP1 VGNC VGNC:37744
Felis catus AJAP1 VGNC VGNC:107485
Mus musculus AJAP1 MGD MGI:2685419
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