MAPK6 - mitogen-activated protein kinase 6 Gene

中文名称：丝裂原活化蛋白激酶 6

种属: Homo sapiens

同用名: ERK3; PRKM6; p97MAPK; HsT17250

关于 MAPK6

功能概要

由该基因编码的蛋白质是 Ser/Thr 蛋白激酶家族的成员，与丝裂原活化蛋白激酶 (MAP 激酶) 的关系最为密切。 MAP 激酶也称为细胞外信号调节激酶 (ERK) ，通过蛋白质磷酸化级联反应被激活，并充当多种生化信号的整合点。这种激酶位于细胞核中，据报道在用血清或佛波醇酯处理后在成纤维细胞中被激活。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]