PDGFC - platelet derived growth factor C Gene

中文名称：血小板衍生生长因子 C

种属: Homo sapiens

同用名: SCDGF; FALLOTEIN

基因 ID: 56034 | 基因类型: protein coding

关于 PDGFC

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:156,760,454-156,971,799 (from NCBI)

This gene has 9 transcripts (splice variants), 204 orthologues and 35 paralogues. Ubiquitous expression in endometrium (RPKM 16.6), prostate (RPKM 13.9) and 24 other tissues.

功能概要

该基因编码的蛋白质是血小板衍生生长因子家族的一员。该家族的四个成员是间充质起源细胞的促有丝分裂因子，其特征在于八个半胱氨酸的核心基序。该基因产物似乎仅形成同型二聚体。它与血小板衍生生长因子 α 和 β 多肽的不同之处在于具有不寻常的 N 末端结构域，即 CUB 结构域。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2010 年 9 月]

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

PDGFC 基因产物(1)

mRNA	Protein	Name
NM_016205.3	NP_057289.1	platelet-derived growth factor C precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables platelet-derived growth factor receptor binding	IPI IPI: 通过物理相互作用推断	10806482	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10806482	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	10806482	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in platelet-derived growth factor receptor signaling pathway	IDA IDA: 通过直接分析推断	10806482	GOA
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	10806482	GOA
involved in positive regulation of fibroblast proliferation	IDA IDA: 通过直接分析推断	10806482	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	10806482	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	10806482	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDGFC 蛋白结构

CUB

PDGF

0
100
200
300
345 a.a.

蛋白主名

其他名称

platelet-derived growth factor C

PDGF-C

PDGFC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PDGFC	Q9NRA1	PDGFRA	Homo sapiens	P16234	Competition Binding	10806482

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PDGFC 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7279	PDGF-CC Protein, Human (HEK293)	Q9NRA1-1 (V235-G345)	≥95%
HY-P73353	PDGF-CC Protein, Human (HEK293, Fc)	Q9NRA1-1 (V235-G345)	≥95%

关联疾病

疾病名称

别名

Milker'S Nodule

Poxviridae Infections	Milker Nodule
Milkers' Node	Paravaccinia
Pseudocowpox	Milker'S Nodes

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Macular Degeneration, Age-Related, 1

Macular Degeneration	Age-Related Macular Degeneration
Macular Degeneration, Age-Related	Age Related Macular Degeneration
Age Related Macular Degeneration 1	ARMD1
Senile Macular Degeneration	Maculopathy, Age-Related, 1
Macular Degeneration, Age-Related, Reduced Risk Of	Age Related Maculopathy 1
Age Related Maculopathies	Age Related Maculopathy
Senile Macular Retinal Degeneration	Macular Degeneration Of Retina
Age-Related Maculopathy	Amd
Armd	Age-Related Maculopathy, Susceptibility To
Maculopathy Age-Related	Macular Degeneration, Age-Related, 1, Susceptibility To
Maculopathy, Age-Related	Macular Degeneration, Age-Related, Type 1
Macular Degeneration, Age-Related, 2

Contagious Pustular Dermatitis

Ecthyma, Contagious	Orf
Ecthyma Contagiosum	Scabby Mouth
Sheep Pox	Thistle Disease
Contagious Pustular Dermatosis

Bronchiectasis 2

Petrous Apex Meningioma

Meningioma Of The Petrous Ridge

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Orofacial Cleft

Cleft, Orofacial

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10252	PDGFC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	PDGFC	VGNC	VGNC:44370
Mus musculus	PDGFC	MGD	MGI:1859631
Rattus norvegicus	PDGFC	RGD	RGD:68410
Bos taurus	PDGFC	VGNC	VGNC:53915
Macaca mulatta	PDGFC	VGNC	VGNC:75928
Felis catus	PDGFC	VGNC	VGNC:68771

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PDGFC - platelet derived growth factor C Gene

关于 PDGFC

功能概要

PDGFC 基因产物(1)

PDGFC 蛋白结构

PDGFC 蛋白互作信息

重组 PDGFC 蛋白

关联疾病

直系同源

热门区域

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PDGFC - platelet derived growth factor C Gene

关于 PDGFC

功能概要

PDGFC 基因产物(1)

PDGFC 蛋白结构

PDGFC 蛋白互作信息

重组 PDGFC 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z