PRKX - protein kinase cAMP-dependent X-linked catalytic subunit Gene

中文名称：蛋白激酶 cAMP 依赖性 X 连锁催化亚基

种属: Homo sapiens

同用名: PKX1

基因 ID: 5613 | 基因类型: protein coding

关于 PRKX

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:3,604,340-3,713,649 (from NCBI)

This gene has 4 transcripts (splice variants), 193 orthologues and 5 paralogues. Broad expression in thyroid (RPKM 22.9), kidney (RPKM 7.3) and 20 other tissues.

功能概要

该基因编码的丝氨酸苏氨酸蛋白激酶与环 AMP 依赖性蛋白激酶的催化亚基具有相似性。编码的蛋白质在发育过程中受到调节，可能参与肾上皮形态发生。这种蛋白质也可能参与巨噬细胞和粒细胞的成熟。该基因与 Y 染色体上相关假基因之间的异常重组是 XX 男性和 XY 女性性反转障碍的常见原因。该基因的假基因存在于染色体 X、15 和 Y 上。[RefSeq 提供，2010 年 2 月]

This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]

PRKX 基因产物(1)

mRNA	Protein	Name
NM_005044.5	NP_005035.1	cAMP-dependent protein kinase catalytic subunit PRKX

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cAMP-dependent protein kinase activity	IDA IDA: 通过直接分析推断	10026146	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16491121	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in angiogenesis	IMP IMP: 通过突变表型推断	21684272	GOA
involved in cell adhesion	IMP IMP: 通过突变表型推断	21684272	GOA
involved in cell-substrate adhesion	IMP IMP: 通过突变表型推断	16491121	GOA
involved in endothelial cell migration	IMP IMP: 通过突变表型推断	21684272	GOA
involved in endothelial cell proliferation	IMP IMP: 通过突变表型推断	21684272	GOA
involved in epithelial tube morphogenesis	IDA IDA: 通过直接分析推断	17980165	GOA
involved in kidney morphogenesis	IDA IDA: 通过直接分析推断	17980165	GOA
involved in myeloid cell differentiation	IDA IDA: 通过直接分析推断	9860982	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	16491121	GOA
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	10026146	GOA
involved in regulation of cell adhesion	IDA IDA: 通过直接分析推断	17980165	GOA
involved in regulation of cell migration	IDA IDA: 通过直接分析推断	17980165	GOA
involved in regulation of epithelial cell differentiation involved in kidney development	IDA IDA: 通过直接分析推断	17980165	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10026146	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10026146	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKX 蛋白结构

Pkinase

0
100
200
300
358 a.a.

蛋白主名

其他名称

cAMP-dependent protein kinase catalytic subunit PRKX

protein kinase PKX1

PRKX 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PRKX	P51817	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	PRKX	P51817	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	PRKX	P51817	PRKAR1A	Homo sapiens	P10644	Y2H	16491121
Intra	PRKX	P51817	PRKAR1A	Homo sapiens	P10644	Anti Tag CoIP	16491121
Intra	PRKX	P51817	GPKOW	Homo sapiens	Q92917	Anti Tag CoIP	16491121
Intra	PRKX	P51817	SMAD6	Homo sapiens	O43541	Anti Bait CoIP	16491121
Intra	PRKX	P51817	SMAD6	Homo sapiens	O43541	Protein Kinase Assay	16491121
Intra	PRKX	P51817	SMAD6	Homo sapiens	O43541	Y2H	16491121
Intra	PRKX	P51817	SMAD6	Homo sapiens	O43541	Anti Tag CoIP	16491121

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Asbestos-Related Lung Carcinoma

Breast Ductal Adenoma

Primary Pigmented Nodular Adrenocortical Disease

Ppnad	Primary Pigmented Nodular Adrenal Dysplasia
Pigmented Nodular Adrenocortical Disease, Primary, 2	Pigmented Nodular Adrenocortical Disease, Primary, 1

Acth-Independent Macronodular Adrenal Hyperplasia

Acth-Independent Macronodular Adrenocortical Hyperplasia	Adrenocorticotropic Hormone-Independent Macronodular Adrenal Hyperplasia
Corticotropin-Independent Macronodular Adrenal Hyperplasia	Cushing Syndrome Due To Macronodular Adrenal Hyperplasia
AIMAH1	Aimah
Massive Macronodular Adrenocortical Disease	Mmad
Primary Macronodular Adrenal Hyperplasia	Cushing Syndrome, Adrenal, Due To Aimah
Primary Bilateral Macronodular Adrenal Hyperplasia	Acth-Independent Macronodular Adrenal Hyperplasia 1
Acth-Independent Cushing Syndrome	Adrenal Cushing Syndrome Due To Aimah
Acth-Independent Macronodular Adrenal Hyperplasia 2

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Carney Complex Variant

Carney Complex	Carney Syndrome
Carney Complex, Type 1	Lamb Syndrome
Name Syndrome	Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome
Carney Complex - Trismus - Pseudocamptodactyly Syndrome	Carney Complex, Type 2
Car	Cnc1
Carney Myxoma-Endocrine Complex	Myxoma - Spotty Pigmentation - Endocrine Overactivity
Myxoma, Spotty Pigmentation, And Endocrine Overactivity	Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome
Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome	Carney Complex-Trismus-Pseudocamptodactyly Syndrome
CACOV

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Breast Adenoma

Ademoma - Breast

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11159	PRKX Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PRKX	MGD	MGI:1309999
Rattus norvegicus	PRKX	RGD	RGD:1564076
Canis familiaris	PRKX	VGNC	VGNC:54833
Others	PRKX	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRKX - protein kinase cAMP-dependent X-linked catalytic subunit Gene

关于 PRKX

功能概要

PRKX 基因产物(1)

PRKX 蛋白结构

PRKX 蛋白互作信息

关联疾病

直系同源

热门区域

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PRKX - protein kinase cAMP-dependent X-linked catalytic subunit Gene

关于 PRKX

功能概要

PRKX 基因产物(1)

PRKX 蛋白结构

PRKX 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

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