PRSS3 - serine protease 3 Gene

中文名称：丝氨酸蛋白酶 3

种属: Homo sapiens

同用名: T9; MTG; TRY3; TRY4; PRSS4

基因 ID: 5646 | 基因类型: protein coding

关于 PRSS3

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,750,679-33,799,231 (from NCBI)

This gene has 7 transcripts (splice variants), 474 orthologues and 3 paralogues. Restricted expression toward pancreas (RPKM 3091.3).

功能概要

该基因编码胰蛋白酶原，它是丝氨酸蛋白酶胰蛋白酶家族的成员。这种酶在大脑和胰腺中表达，对常见的胰蛋白酶抑制剂有抵抗力。它对涉及赖氨酸或精氨酸羧基的肽键具有活性。该基因定位于 9 号染色体上 T 细胞受体 β 可变孤儿的基因座。已针对该基因描述了编码不同亚型的四种转录物变体。[RefSeq 提供，2010 年 10 月]

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This Enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]

PRSS3 基因产物(4)

mRNA	Protein	Name
NM_001197097.3	NP_001184026.3	trypsin-3 isoform 3 preproprotein
NM_001197098.1	NP_001184027.1	trypsin-3 isoform 4 preproprotein
NM_002771.4	NP_002762.3	trypsin-3 isoform 2 preproprotein
NM_007343.4	NP_031369.3	trypsin-3 isoform 1 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium ion binding	IDA IDA: 通过直接分析推断	6698368	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	6698368	GOA
enables serine-type endopeptidase activity	IDA IDA: 通过直接分析推断	6698368	GOA
enables serine-type peptidase activity	IDA IDA: 通过直接分析推断	9099703	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in endothelial cell migration	IMP IMP: 通过突变表型推断	15313892	GOA
involved in proteolysis	IDA IDA: 通过直接分析推断	6698368	GOA
involved in zymogen activation	IDA IDA: 通过直接分析推断	6698368	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	6698368	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRSS3 蛋白结构

Trypsin

0
100
200
304 a.a.

蛋白主名

其他名称

trypsin-3

brain trypsinogen

重组 PRSS3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71456	PRSS3/Trypsin-3 Protein, Human (His)	P35030 (I81-N303)	≥95%
HY-P75985	PRSS3/Trypsin-3 Protein, Human (HEK293, His)	P35030-3 (V16-S247)	≥95%

关联疾病

疾病名称

别名

Thyroiditis

Inflammation Of Thyroid

Thyroiditis Nos

Hashimoto Thyroiditis

Autoimmune Thyroiditis	Hashimoto Struma
Hashimoto'S Thyroiditis	Chronic Lymphocytic Thyroiditis
Lymphocytic Thyroiditis	Hashimoto Disease
Ht	Hashimoto'S Disease
Hashimoto'S Syndrome	Hypothyroidism, Autoimmune
Autoimmune Chronic Lymphocytic Thyroiditis	Chronic Lymphocytic Thyroiditides
Hashimoto Syndrome	Hashimotos Thyroiditis
Hashimoto Thyroiditis, Susceptibility To	Thyroiditis, Autoimmune
Lymphomatous Thyroiditis	Lymphoid Thyroiditis
Chronic Lymphadenoid Thyroiditis	Autoimmune Lymphocytic Chronic Thyroiditis
Goitre Lymphomatosa	Hashitoxicosis
Hashimoto Hypothyroidism	Lymphadenoid Goitre
Struma Lymphomatosa	Hyperthyroidism With Hashimoto Disease
Hashimoto Thyrotoxicosis	Thyrotoxicosis Due To Hashimoto Thyroiditis
Struma Lymphomatosis	Lymphadenoid Struma

Pancreatitis

Mumps Pancreatitis

Pancreatitis, Hereditary

Hereditary Pancreatitis	Chronic Pancreatitis
Hereditary Chronic Pancreatitis	Hp
Pancreatitis, Chronic, Susceptibility To	PCTT
Hpc	Pancreatitis, Chronic
Pancreatitis, Chronic, Protection Against	Autosomal Dominant Hereditary Pancreatitis
Familial Pancreatitis	Cp
Pancreatitis Hereditary

Autoimmune Disease Of Endocrine System

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11253	PRSS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PRSS3	RGD	RGD:1311446
Others	PRSS3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRSS3 - serine protease 3 Gene

关于 PRSS3

功能概要

PRSS3 基因产物(4)

PRSS3 蛋白结构

重组 PRSS3 蛋白

关联疾病

直系同源

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PRSS3 - serine protease 3 Gene

关于 PRSS3

功能概要

PRSS3 基因产物(4)

PRSS3 蛋白结构

重组 PRSS3 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z