2. Gene
  3. Rapgef4 - Rap guanine nucleotide exchange factor (GEF) 4 Gene

Rapgef4 - Rap guanine nucleotide exchange factor (GEF) 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Epac2; EPAC 2; Epac-2; mKIAA4040; 1300003D15Rik; 5730402K07Rik; 6330581N18Rik

基因 ID: 56508 | 基因类型: protein coding

关于 Rapgef4

功能概要

Enables cAMP binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Involved in regulation of synaptic vesicle cycle. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Located in cytosol and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including adrenal gland; ganglia; heart; lung; and metanephros. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human RAPGEF4 (Rap guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Rapgef4 基因产物(5)

mRNA Protein Name
NM_001204165.1 NP_001191094.1 rap guanine nucleotide exchange factor 4 isoform 1
NM_001204166.1 NP_001191095.1 rap guanine nucleotide exchange factor 4 isoform 3
NM_001204167.1 NP_001191096.1 rap guanine nucleotide exchange factor 4 isoform 4
NM_001355478.1 NP_001342407.1 rap guanine nucleotide exchange factor 4 isoform 5
NM_019688.2 NP_062662.1 rap guanine nucleotide exchange factor 4 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cAMP binding IDA
IDA: 通过直接分析推断
18660803 MGI
enables guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
11056535 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12401793 MGI
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
11056535 MGI
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
18660803 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
11598134 MGI
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
11598134 MGI
acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
11056535 MGI
acts upstream of or within calcium-ion regulated exocytosis IDA
IDA: 通过直接分析推断
11056535 MGI
acts upstream of or within positive effect hormone secretion IMP
IMP: 通过突变表型推断
23542788 MGI
acts upstream of or within insulin secretion IDA
IDA: 通过直接分析推断
11598134 MGI
involved in positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
11598134 MGI
acts upstream of or within regulation of exocytosis IDA
IDA: 通过直接分析推断
12401793 MGI
involved in regulation of synaptic vesicle cycle IDA
IDA: 通过直接分析推断
25904804 MGI
involved in regulation of synaptic vesicle cycle IMP
IMP: 通过突变表型推断
25904804 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytosol IDA
IDA: 通过直接分析推断
11056535 MGI
located in cytosol IDA
IDA: 通过直接分析推断
11056535 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: 通过直接分析推断
25904804 MGI
is active in hippocampal mossy fiber to CA3 synapse IMP
IMP: 通过突变表型推断
25904804 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

rap guanine nucleotide exchange factor 4

cAMP-GEFII

cAMP-dependent Rap1 guanine-nucleotide exchange factor

cAMP-regulated guanine nucleotide exchange factor IIB

exchange factor directly activated by cAMP 2

exchange protein directly activated by cAMP 2

Rapgef4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Rapgef4 Q9EQZ6 HRAS Homo sapiens P01112
Pull Down
16316996
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11663 RAPGEF4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rapgef4 NCBI NCBI:11069
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