AZU1 - azurocidin 1 Gene

中文名称：天青素 1

种属: Homo sapiens

同用名: AZU; HBP; NAZC; hHBP; AZAMP; CAP37; HUMAZUR

基因 ID: 566 | 基因类型: protein coding

关于 AZU1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:827,837-832,018 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 238 orthologues and 6 paralogues. Restricted expression toward bone marrow (RPKM 1256.4).

功能概要

Azurophil granules 是中性粒细胞的特殊溶酶体，含有至少 10 种与杀死微生物有关的蛋白质。该基因编码一种前原蛋白，该蛋白经过蛋白水解处理后生成成熟的嗜苯胺青颗粒抗生素蛋白，具有单核细胞趋化性和抗菌活性。它也是一种重要的多功能炎症介质。这种编码的蛋白质是丝氨酸蛋白酶基因家族的成员，但它不是丝氨酸蛋白酶，因为活性位点丝氨酸和组氨酸残基被替换。编码这种蛋白质、中性粒细胞弹性蛋白酶 2 和蛋白酶 3 的基因位于染色体 19pter 的簇中。所有 3 个基因协调表达，它们的蛋白质产物在中性粒细胞分化过程中一起包装成天青粒细胞颗粒。[RefSeq 提供，2015 年 11 月]

Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of Microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule Antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine Protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil Elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015]

AZU1 基因产物(1)

mRNA	Protein	Name
NM_001700.5	NP_001691.1	azurocidin preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables heparan sulfate proteoglycan binding	IDA IDA: 通过直接分析推断	15879141	GOA
enables heparin binding	IMP IMP: 通过突变表型推断	11994286	GOA
enables peptidase activity	IDA IDA: 通过直接分析推断	21550830	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11994286	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antimicrobial humoral response	IMP IMP: 通过突变表型推断	11994286	GOA
involved in cell chemotaxis	IMP IMP: 通过突变表型推断	24008408	GOA
involved in defense response to virus	IMP IMP: 通过突变表型推断	19274533	GOA
involved in glial cell migration	IDA IDA: 通过直接分析推断	12465046	GOA
involved in intracellular signal transduction	IMP IMP: 通过突变表型推断	24008408	GOA
involved in microglial cell activation	IEP IEP: 通过表达模式推断	12465046	GOA
involved in monocyte extravasation	IDA IDA: 通过直接分析推断	15879141	GOA
involved in neutrophil-mediated killing of bacterium	IDA IDA: 通过直接分析推断	2312733	GOA
involved in positive regulation of MHC class II biosynthetic process	IEP IEP: 通过表达模式推断	12465046	GOA
involved in positive regulation of cell adhesion	IDA IDA: 通过直接分析推断	12826073	GOA
involved in positive regulation of fractalkine production	IDA IDA: 通过直接分析推断	12465046	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: 通过直接分析推断	12465046	GOA
involved in positive regulation of phagocytosis	IDA IDA: 通过直接分析推断	12465046	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: 通过直接分析推断	12465046	GOA
involved in proteolysis	IDA IDA: 通过直接分析推断	21550830	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in azurophil granule	IDA IDA: 通过直接分析推断	11861296	GOA
located in azurophil granule membrane	IDA IDA: 通过直接分析推断	2312733	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	15879141	GOA
located in membrane	IDA IDA: 通过直接分析推断	2312733	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AZU1 蛋白结构

Trypsin

0
100
200
251 a.a.

蛋白主名

其他名称

azurocidin

cationic antimicrobial protein 37

重组 AZU1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7624	Azurocidin Protein, Human (HEK293, His)	P20160 (I27-P250)	≥95%

关联疾病

疾病名称

别名

Erysipelas

Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome

Jacobs Syndrome	Arthropathy-Camptodactyly Syndrome
Pericarditis-Arthropathy-Camptodactyly Syndrome	Xyy Syndrome
Pac Syndrome	Cacp Syndrome
CACP	Fibrosing Serositis, Familial
Camptodactyly-Arthropathy-Pericarditis Syndrome	Cap Syndrome
47, Xyy Syndrome	47,Xyy Syndrome
Double Y Syndrome	Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome
Hypertrophic Synovitis, Congenital Familial	Congenital Familial Hypertrophic Synovitis
Xyy Karyotype	Y Disomy
Yy Syndrome	Familial Fibrosing Serositis
Disomy Y	Double Y
Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome	Arthropathy Camptodactyly Syndrome
Camptodactyly Arthropathy Pericarditis Syndrome	Pericarditis Arthropathy Camptodactyly Syndrome
Jacob'S Syndrome	47,Xyy
Cdags Syndrome

Dacryocystitis

Nasolacrimal Sac Infection

Acute Inflammation Of Lacrimal Passage

Cornea Cancer

Malignant Neoplasm Of Cornea	Neoplasm Of Cornea
Corneal Tumor	Malignant Corneal Tumor
Malignant Tumor Of Cornea	Primary Malignant Neoplasm Of Cornea

Congenital Disorder Of Glycosylation, Type Ig

CDG1G	Alg12-Congenital Disorder Of Glycosylation
Cdg Ig	Congenital Disorder Of Glycosylation Type 1g
Congenital Disorder Of Glycosylation Type Ig	Cdgig
Congenital Disorder Of Glycosylation Ig	Congenital Disorder Of Glycosylation 1g
Cdg-Ig	Alg12-Cdg
Cdg Syndrome Type Ig	Carbohydrate Deficient Glycoprotein Syndrome Type Ig
Mannosyltransferase 8 Deficiency	Glycosylation, Congenital Disorder Of, Type Ig

Hepatic Veno-Occlusive Disease

Veno-Occlusive Disease	Sinusoidal Obstruction Syndrome
Hepatic Venoocclusive Disease	Venoocclusive Disease
Hepatic Vein Thrombosis	Budd-Chiari Syndrome
Hepatic Vein Occlusion	Veno-Occlusive Disease Of The Liver

Viral Meningitis

Meningitis Viral	Meningitis, Viral
Viral Meningitis Nec

Pericarditis

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Necrotizing Fasciitis

Fasciitis, Necrotizing

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