BCCIP - BRCA2 and CDKN1A interacting protein Gene

中文名称：BRCA2 和 CDKN1A 相互作用蛋白

种属: Homo sapiens

同用名: TOK1; TOK-1

关于 BCCIP

功能概要

该基因产物是根据其与 BRCA2 和 p21 蛋白的相互作用而分离出来的。它是一种进化上保守的核蛋白，具有多个相互作用的结构域。 N 末端的一半与钙调蛋白和 M-钙蛋白酶区域具有适度的同源性，表明它也可能结合钙。功能研究表明，该蛋白可能是 BRCA2 在肿瘤抑制中的重要辅助因子，并且是通过 p21 调节 CDK2 激酶活性的因子。这种蛋白质还涉及 BRCA2 和 RAD51 核焦点形成、双链断裂诱导的同源重组和细胞周期进程的调节。已针对该基因描述了编码不同亚型的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of Calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]