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  2. RPL23 - ribosomal protein L23 Gene

RPL23 - ribosomal protein L23 Gene

中文名称:核糖体蛋白 L23

种属: Homo sapiens

同用名: L23; rpL17

基因 ID: 9349 | 基因类型: protein coding

关于 RPL23

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,847,860-38,853,721 (from NCBI)

This gene has 11 transcripts (splice variants) and 260 orthologues. Ubiquitous expression in ovary (RPKM 1299.4), bone marrow (RPKM 656.3) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器,由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 60S 亚基的一个组成部分。该蛋白属于核糖体蛋白 L14P 家族。它位于细胞质中。该基因被称为 rpL17,因为编码的蛋白质与来自酿酒酵母的核糖体蛋白 L17 具有氨基酸同一性;但是,它的官方符号是 RPL23。作为典型的编码核糖体蛋白的基因,该基因有多个经过处理的假基因分散在基因组中。[RefSeq 提供,2008 年 7 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL23 基因产物(1)

mRNA Protein Name
NM_000978.4 NP_000969.1 60S ribosomal protein L23
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15314173 GOA
enables structural constituent of ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
enables transcription coactivator binding IPI
IPI: 通过物理相互作用推断
19160485 GOA
enables ubiquitin ligase inhibitor activity IDA
IDA: 通过直接分析推断
15314173 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
15314173 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15314173 GOA
part of cytosolic large ribosomal subunit IDA
IDA: 通过直接分析推断
32669547 GOA
part of cytosolic large ribosomal subunit IPI
IPI: 通过物理相互作用推断
25901680 GOA
located in cytosolic ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
15314173 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
15314173 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
19160485 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
15314173 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RPL23 蛋白结构

Ribosomal_L14

Ribosomal_L14: Ribosomal protein L14p/L23e (21 - 138)

  • 0
  • 100
  • 140 a.a.
蛋白主名 其他名称

60S ribosomal protein L23

60S ribosomal protein L17

RPL23 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPL23 P62829 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
RPL23 P62829 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
RPL23 P62829 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
RPL23 P62829 MDM2 Homo sapiens Q00987
Anti Bait CoIP
17110929
种属内
RPL23 P62829 MDM2 Homo sapiens Q00987
Y2H
17310983
种属内
RPL23 P62829 BCCIP Homo sapiens Q9P287
Validated Y2H
32296183
种属内
RPL23 P62829 BCCIP Homo sapiens Q9P287
Validated Y2H
25416956
种属内
RPL23 P62829 BCCIP Homo sapiens Q9P287
Y2H Array
25416956
种属内
RPL23 P62829 BCCIP Homo sapiens Q9P287
Y2H Pooling
16189514
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spondylometaphyseal Dysplasia, Sedaghatian Type

SMDS

Sedaghatian Chondrodysplasia

Spondylometaphyseal Dysplasia Sedaghatian Type

Congenital Lethal Metaphyseal Chondrodysplasia

Metaphyseal Chondrodysplasia, Congenital Lethal

Lethal Metaphyseal Dysplasia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus RPL23 MGD MGI:1929455
Rattus norvegicus RPL23 RGD RGD:62067
Macaca mulatta RPL23 VGNC VGNC:104646
Felis catus RPL23 VGNC VGNC:99437
Bos taurus RPL23 VGNC VGNC:55867