1. Gene
  2. MUC13 - mucin 13, cell surface associated Gene

MUC13 - mucin 13, cell surface associated Gene

中文名称:粘蛋白 13,细胞表面相关

种属: Homo sapiens

同用名: DRCC1; MUC-13

基因 ID: 56667 | 基因类型: protein coding

关于 MUC13

Cytogenetic location: 3q21.2 Genomic coordinates (GRCh38): 3:124,905,442-124,934,751 (from NCBI)

This gene has 5 transcripts (splice variants), 82 orthologues and 2 paralogues. Biased expression in duodenum (RPKM 317.3), small intestine (RPKM 271.9) and 4 other tissues.

功能概要

上皮粘蛋白,例如 MUC13,是由导管和腺上皮组织表达的分泌型和细胞表面糖蛋白家族 (Williams 等人,2001 [PubMed 11278439]) 。[OMIM 提供,2008 年 7 月]

Epithelial mucins, such as MUC13, are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues (Williams et al., 2001 [PubMed 11278439]).[supplied by OMIM, Jul 2008]

MUC13 基因产物(1)

mRNA Protein Name
NM_033049.4 NP_149038.3 mucin-13 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
11278439 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in maintenance of gastrointestinal epithelium IMP
IMP: 通过突变表型推断
17058067 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
11278439 GOA
located in cytosol IMP
IMP: 通过突变表型推断
11278439 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
11278439 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MUC13 蛋白结构

SEA

SEA: SEA domain (211 - 321)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 511 a.a.
蛋白主名 其他名称

mucin-13

down-regulated in colon cancer 1

关联疾病

疾病名称 别名
Holoprosencephaly 2

HPE2

Holoprosencephaly-2

Holoprosencephaly, Type 2

Bile Duct Cystadenocarcinoma

Biliary Cystadenocarcinoma

Intrahepatic Bile Duct Cystadenocarcinoma

Intrahepatic Bile Duct Mucinous Cystic Neoplasm With An Associated Invasive Carcinoma

Lymphohistiocytoid Mesothelioma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus MUC13 VGNC VGNC:68358
Mus musculus MUC13 MGD MGI:103190
Rattus norvegicus MUC13 RGD RGD:708547
Macaca mulatta MUC13 VGNC VGNC:84151
Canis familiaris MUC13 VGNC VGNC:43498
Bos taurus MUC13 VGNC VGNC:31758