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  3. ZC3HAV1 - zinc finger CCCH-type containing, antiviral 1 Gene

ZC3HAV1 - zinc finger CCCH-type containing, antiviral 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含锌指 CCCH 型，抗病毒 1

种属: Homo sapiens

同用名: ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2

基因 ID: 56829 | 基因类型: protein coding

关于 ZC3HAV1

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:139,043,515-139,109,720 (from NCBI)

This gene has 5 transcripts (splice variants), 124 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 17.0), lymph node (RPKM 9.0) and 24 other tissues.

功能概要

该基因编码 CCCH 型锌指蛋白。这种抗病毒蛋白通过募集细胞 RNA 降解机制来降解病毒 mRNA，从而抑制病毒复制。编码的蛋白质在针对多种 DNA 和 RNA 病毒的先天免疫反应中发挥重要作用，包括埃博拉病毒、HIV 和 SARS-CoV-2 (导致 COVID-19) 。[RefSeq 提供，2021 年 9 月]

This gene encodes a CCCH-type zinc finger protein. This Antiviral protein inhibits viral replication by recruiting cellular RNA degradation machineries to degrade viral mRNAs. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses, including Ebola virus, HIV and SARS-CoV-2 (which causes COVID-19). [provided by RefSeq, Sep 2021]

ZC3HAV1 基因产物(3)

mRNA Protein Name
NM_001363491.2 NP_001350420.1 zinc finger CCCH-type antiviral protein 1 isoform 3
NM_020119.4 NP_064504.2 zinc finger CCCH-type antiviral protein 1 isoform 1
NM_024625.4 NP_078901.3 zinc finger CCCH-type antiviral protein 1 isoform 2

ZC3HAV1 蛋白结构

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (728 - 894)

  • 0
  • 200
  • 400
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  • 800
  • 902 a.a.
蛋白主名 其他名称

zinc finger CCCH-type antiviral protein 1

ADP-ribosyltransferase diphtheria toxin-like 13

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15997 ZC3HAV1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ZC3HAV1 VGNC VGNC:48563
Mus musculus ZC3HAV1 MGD MGI:1926031
Bos taurus ZC3HAV1 VGNC VGNC:37111
Macaca mulatta ZC3HAV1 VGNC VGNC:79408
Felis catus ZC3HAV1 VGNC VGNC:67191
Rattus norvegicus ZC3HAV1 RGD RGD:628694
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