2. Gene
  3. GPR137 - G protein-coupled receptor 137 Gene

GPR137 - G protein-coupled receptor 137 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 137

种属: Homo sapiens

同用名: C11orf4; GPR137A; TM7SF1L1

基因 ID: 56834 | 基因类型: protein coding

关于 GPR137

This gene has 19 transcripts (splice variants), 175 orthologues and 2 paralogues. Broad expression in testis (RPKM 30.3), brain (RPKM 9.0) and 24 other tissues.

功能概要

预计参与多个过程，包括骨吸收的负调节；破骨细胞分化的负调节；和 TORC1 信号的正调控。位于溶酶体膜。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to be involved in several processes, including negative regulation of bone resorption; negative regulation of osteoclast differentiation; and positive regulation of TORC1 signaling. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR137 基因产物(18)

mRNA Protein Name
NM_001170880.2 NP_001164351.1 integral membrane protein GPR137 isoform 2
NM_001170881.2 NP_001164352.1 integral membrane protein GPR137 isoform 1
NM_001177358.2 NP_001170829.1 integral membrane protein GPR137 isoform 5
NM_001378076.1 NP_001365005.1 integral membrane protein GPR137 isoform 1
NM_001378077.1 NP_001365006.1 integral membrane protein GPR137 isoform 1
NM_001378078.1 NP_001365007.1 integral membrane protein GPR137 isoform 2
NM_001378079.1 NP_001365008.1 integral membrane protein GPR137 isoform 2
NM_001378080.1 NP_001365009.1 integral membrane protein GPR137 isoform 2
NM_001378081.1 NP_001365010.1 integral membrane protein GPR137 isoform 2
NM_001378082.1 NP_001365011.1 integral membrane protein GPR137 isoform 2
NM_001378083.1 NP_001365012.1 integral membrane protein GPR137 isoform 3
NM_001378084.1 NP_001365013.1 integral membrane protein GPR137 isoform 5
NM_001378085.1 NP_001365014.1 integral membrane protein GPR137 isoform 5
NM_001378086.1 NP_001365015.1 integral membrane protein GPR137 isoform 5
NM_001378087.1 NP_001365016.1 integral membrane protein GPR137 isoform 6
NM_001378088.1 NP_001365017.1 integral membrane protein GPR137 isoform 6
NM_001378089.1 NP_001365018.1 integral membrane protein GPR137 isoform 7
NM_020155.4 NP_064540.3 integral membrane protein GPR137 isoform 3
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in lysosomal membrane IDA
IDA: 通过直接分析推断
31036939 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

integral membrane protein GPR137

transmembrane 7 superfamily member 1-like 1 protein

关联疾病

疾病名称 别名
Retinitis Pigmentosa 60

RP60

Retinitis Pigmentosa, Type 60
Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib

IGHD1B

Ighd Ib

Growth Hormone Deficiency, Isolated, Type Ib

Congenital Ighd Type Ib

Congenital Isolated Gh Deficiency Type Ib

Congenital Isolated Growth Hormone Deficiency Type Ib

Dwarfism Of Sindh

Pituitary Dwarfism I

Isolated Growth Hormone Deficiency Type 1b

Ighd 1b

Growth Hormone Deficiency, Isolated, 1b
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05658 GPR137 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05659 GPR137B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GPR137 MGD MGI:2147529
Macaca mulatta GPR137 VGNC VGNC:72994
Bos taurus GPR137 VGNC VGNC:29550
Canis familiaris GPR137 VGNC VGNC:41397
Rattus norvegicus GPR137 RGD RGD:1586317
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