MDM1 - Mdm1 nuclear protein Gene

中文名称：Mdm1 核蛋白

种属: Homo sapiens

基因 ID: 56890 | 基因类型: protein coding

关于 MDM1

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:68,294,566-68,332,362 (from NCBI)

This gene has 16 transcripts (splice variants) and 182 orthologues. Broad expression in testis (RPKM 7.9), endometrium (RPKM 4.1) and 24 other tissues.

功能概要

该基因编码一种微管结合核蛋白，定位于分裂细胞和分化多纤毛细胞的中心粒，负调节中心粒复制。编码的蛋白质与中心粒桶密切相关，位于中心粒腔内。直系同源小鼠基因中自然发生的突变与年龄相关的视网膜变性有关。[RefSeq 提供，2019 年 2 月]

This gene encodes a microtubule-binding nuclear protein that localizes to the centrioles of dividing cells and differentiating multiciliated cells and negatively regulates centriole duplication. The encoded protein is closely associated with the centriole barrel, and resides in the centriole lumen. Naturally-occurring mutations in the orthologous mouse gene are associated with age-related retinal degeneration. [provided by RefSeq, Feb 2019]

MDM1 基因产物(11)

mRNA	Protein	Name
NM_001205028.3	NP_001191957.1	nuclear protein MDM1 isoform 4
NM_001205029.3	NP_001191958.1	nuclear protein MDM1 isoform 3
NM_001354969.2	NP_001341898.1	nuclear protein MDM1 isoform 5
NM_001354970.2	NP_001341899.1	nuclear protein MDM1 isoform 6
NM_001354971.2	NP_001341900.1	nuclear protein MDM1 isoform 7
NM_001354972.2	NP_001341901.1	nuclear protein MDM1 isoform 7
NM_001354973.2	NP_001341902.1	nuclear protein MDM1 isoform 7
NM_001354974.2	NP_001341903.1	nuclear protein MDM1 isoform 8
NM_001368282.1	NP_001355211.1	nuclear protein MDM1 isoform 7
NM_017440.6	NP_059136.2	nuclear protein MDM1 isoform 1
NM_020128.4	NP_064513.1	nuclear protein MDM1 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables microtubule binding	IMP IMP: 通过突变表型推断	26337392	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of centriole replication	IMP IMP: 通过突变表型推断	26337392	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centriole	IDA IDA: 通过直接分析推断	26337392	GOA
located in centrosome	IDA IDA: 通过直接分析推断	26337392	GOA
located in nucleus	IDA IDA: 通过直接分析推断	26337392	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MDM1 蛋白结构

MDM1

0
200
400
600
714 a.a.

蛋白主名

其他名称

nuclear protein MDM1

Mdm4, transformed 3T3 cell double minute 1, p53 binding protein

MDM1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MDM1	Q8TC05	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Prey Pooling	32296183
种属内	MDM1	Q8TC05	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Array	32296183
种属内	MDM1	Q8TC05	POC1A	Homo sapiens	Q8NBT0	Anti Tag CoIP	33961781
种属内	MDM1	Q8TC05	POC1A	Homo sapiens	Q8NBT0	Anti Tag CoIP	28514442
种属内	MDM1	Q8TC05	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	32296183
种属内	MDM1	Q8TC05	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
种属内	MDM1	Q8TC05	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Spinocerebellar Ataxia, Autosomal Recessive 20

Autosomal Recessive Spinocerebellar Ataxia 20	SCAR20
Intellectual Disability-Coarse Face-Macrocephaly-Cerebellar Hypotrophy Syndrome	Autosomal Recessive Spinocerebellar Ataxia Type 20
Intellectual Disability-Coarse Face-Macrocephaly-Cerebellar Hypoplasia Syndrome	Spinocerebellar Ataxia, Autosomal Recessive, 20
Ataxia, Spinocerebellar, Autosomal Recessive, Type 20

Retinal Degeneration

Degeneration Of Retina

Choreoacanthocytosis

Chorea-Acanthocytosis	CHAC
Acanthocytosis With Neurologic Disorder	Levine-Critchley Syndrome
Choreaacanthocytosis	Chorea Acanthocytosis
Neuroacanthocytosis	Levine-Critchley Syndrome, Formerly
Neuroacanthocytosis, Formerly	Choreo-Acanthocytosis
Acanthocytosis Chorea	Chorea Acanthocytosis Syndrome

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-15997	(-)-U-50488 hydrochloride	Inhibitor	99.71%	否
HY-RS08263	MDM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-155407	ALR-6	Antagonist	/	否
HY-155408	ALR-27	Antagonist	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	MDM1	VGNC	VGNC:43105
Macaca mulatta	MDM1	VGNC	VGNC:74622
Felis catus	MDM1	VGNC	VGNC:63427
Bos taurus	MDM1	VGNC	VGNC:31335
Mus musculus	MDM1	MGD	MGI:96951
Rattus norvegicus	MDM1	RGD	RGD:1561092

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MDM1 - Mdm1 nuclear protein Gene

关于 MDM1

功能概要

MDM1 基因产物(11)

MDM1 蛋白结构

MDM1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

MDM1 - Mdm1 nuclear protein Gene

关于 MDM1

功能概要

MDM1 基因产物(11)

MDM1 蛋白结构

MDM1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z