TCIM - transcriptional and immune response regulator Gene

中文名称：转录和免疫反应调节因子

种属: Homo sapiens

同用名: TC1; TC-1; C8orf4

基因 ID: 56892 | 基因类型: protein coding

关于 TCIM

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:40,153,482-40,155,310 (from NCBI)

This gene has 1 transcript (splice variant) and 200 orthologues.

功能概要

该基因编码一种小的、单体的、主要是非结构化的蛋白质，作为 Wnt/β-连环蛋白信号通路的正调节剂发挥作用。这种蛋白质与核斑点处的 β-连环蛋白介导的转录阻遏物相互作用。它被认为可以竞争性地阻断阻遏物与 β-连环蛋白的相互作用，从而导致 β-连环蛋白靶基因的上调。编码的蛋白质也可能在 NF-kappaB 和 ERK1/2 信号通路中发挥作用。该基因的表达可能在多种癌症的增殖中发挥作用，包括甲状腺癌、乳腺癌和血液系统恶性肿瘤。[RefSeq 提供，2011 年 11 月]

This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of Cancer including thyroid Cancer, breast Cancer and hematological malignancies. [provided by RefSeq, Nov 2011]

TCIM 基因产物(1)

mRNA	Protein	Name
NM_020130.5	NP_064515.2	transcriptional and immune response regulator

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables Notch binding	IPI IPI: 通过物理相互作用推断	25985737	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16424001	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to heat	IDA IDA: 通过直接分析推断	17603013	GOA
involved in endothelial cell activation involved in immune response	IDA IDA: 通过直接分析推断	19684084	GOA
involved in negative regulation of Notch signaling pathway	IDA IDA: 通过直接分析推断	25985737	GOA
involved in negative regulation of apoptotic process	IDA IDA: 通过直接分析推断	15087392	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	19684084	GOA
involved in positive regulation of protein kinase A signaling	IDA IDA: 通过直接分析推断	15087392	GOA
involved in positive regulation of protein kinase C activity	IDA IDA: 通过直接分析推断	15087392	GOA
involved in regulation of cell cycle G1/S phase transition	IDA IDA: 通过直接分析推断	18959821	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	16424001	GOA
located in nuclear speck	IDA IDA: 通过直接分析推断	16424001	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	16424001	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16424001	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TCIM 蛋白结构

TC1

0
100
106 a.a.

蛋白主名

其他名称

transcriptional and immune response regulator

human thyroid cancer 1

关联疾病

疾病名称

别名

Exudative Vitreoretinopathy 3

EVR3

Hypertrichosis Universalis Congenita, Ambras Type

Ambras Syndrome	Hypertrichosis, Congenital Generalized
HTC1	HTC2
Chromosome Xq27.1 Interchromosomal Insertion Syndrome	Cgh
Hcg	Ambras Type Hypertrichosis Universalis Congenita
X-Linked Congenital Generalized Hypertrichosis	Congenital Generalized Hypertrichosis, Macias-Flores Type
Macias Flores-Garcia Cruz-Rivera Syndrome	Htc 1
Hypertrichosis Universalis Congenita Ambras Type	Hypertrichosis Congenital Generalized X-Linked
Macias-Flores Garcia-Cruz Rivera Syndrome	Congenital Generalized Hypertrichosis, Ambras Type

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14314	TCIM Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TCIM	RGD	RGD:6499724
Mus musculus	TCIM	MGD	MGI:1916318
Bos taurus	TCIM	VGNC	VGNC:49157
Felis catus	TCIM	VGNC	VGNC:66030
Macaca mulatta	TCIM	VGNC	VGNC:84123
Canis familiaris	TCIM	VGNC	VGNC:49590

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TCIM - transcriptional and immune response regulator Gene

关于 TCIM

功能概要

TCIM 基因产物(1)

TCIM 蛋白结构

关联疾病

直系同源

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TCIM - transcriptional and immune response regulator Gene

关于 TCIM

功能概要

TCIM 基因产物(1)

TCIM 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z