2. Gene
  3. NCLN - nicalin Gene

NCLN - nicalin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：尼卡林

种属: Homo sapiens

同用名: NET59

基因 ID: 56926 | 基因类型: protein coding

关于 NCLN

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,185,930-3,209,575 (from NCBI)

This gene has 8 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in colon (RPKM 14.1), duodenum (RPKM 12.9) and 25 other tissues.

功能概要

启用核糖体结合活性。参与蛋白质稳定；调节蛋白质复合物的稳定性；和调节含蛋白质的复合物装配。位于内质网膜上。部分含蛋白质复合物。 [由基因组资源联盟提供，2022 年 4 月]

Enables ribosome binding activity. Involved in protein stabilization; regulation of protein complex stability; and regulation of protein-containing complex assembly. Located in endoplasmic reticulum membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

NCLN 基因产物(2)

mRNA Protein Name
NM_001321463.2 NP_001308392.1 nicalin isoform 2 precursor
NM_020170.4 NP_064555.2 nicalin isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17261586 GOA
enables ribosome binding IDA
IDA: 通过直接分析推断
32820719 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in multi-pass transmembrane protein insertion into ER membrane IDA
IDA: 通过直接分析推断
36261522 GOA
involved in protein stabilization IMP
IMP: 通过突变表型推断
20538592 GOA
involved in regulation of protein complex stability IDA
IDA: 通过直接分析推断
20538592 GOA
involved in regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
20538592 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
20538592 GOA
part of multi-pass translocon complex IDA
IDA: 通过直接分析推断
36261522 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
20538592 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NCLN 蛋白结构

Peptidase_M28

Peptidase_M28: Peptidase family M28 (218 - 383)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 563 a.a.
蛋白主名 其他名称

nicalin

nicalin homolog

NCLN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NCLN Q969V3 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
NCLN Q969V3 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
NCLN Q969V3 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon
Lissencephaly 4

LIS4

Lissencephaly 4 With Microcephaly

Microlissencephaly

Lissencephaly, Type 4
Janus Kinase-3 Deficiency
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome

Berdon Syndrome

MMIHS

Megacystis Microcolon Intestinal Hypoperistalsis Syndrome

Megacystis, Microcolon, Hypoperistalsis Syndrome

Visceral Myopathy

Mmih Syndrome

Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome

MMIHS1

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih

Mmhs
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09087 NCLN Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NCLN RGD RGD:1309355
Felis catus NCLN VGNC VGNC:80632
Mus musculus NCLN MGD MGI:1926081
Bos taurus NCLN VGNC VGNC:31919
Macaca mulatta NCLN VGNC VGNC:75032
Canis familiaris NCLN VGNC VGNC:43658
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