1. Gene
  2. ENY2 - ENY2 transcription and export complex 2 subunit Gene

ENY2 - ENY2 transcription and export complex 2 subunit Gene

中文名称:ENY2 转录和输出复合体 2 亚基

种属: Homo sapiens

同用名: DC6; Sus1; e(y)2

基因 ID: 56943 | 基因类型: protein coding

关于 ENY2

Cytogenetic location: 8q23.1 Genomic coordinates (GRCh38): 8:109,334,347-109,345,954 (from NCBI)

This gene has 16 transcripts (splice variants) and 261 orthologues. Ubiquitous expression in kidney (RPKM 15.2), bone marrow (RPKM 14.0) and 25 other tissues.

功能概要

启用核受体共激活因子活性。参与组蛋白去泛素化; poly (A) + mRNA 从细胞核输出;和转录的正调控,DNA 模板。位于线粒体和核质中。核的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables nuclear receptor coactivator activity. Involved in histone deubiquitination; poly(A)+ mRNA export from nucleus; and positive regulation of transcription, DNA-templated. Located in mitochondrion and nucleoplasm. Part of nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ENY2 基因产物(2)

mRNA Protein Name
NM_001193557.2 NP_001180486.1 transcription and mRNA export factor ENY2 isoform 2
NM_020189.6 NP_064574.1 transcription and mRNA export factor ENY2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear receptor coactivator activity IDA
IDA: 通过直接分析推断
18206972 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23591820 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
18206972 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in poly(A)+ mRNA export from nucleus IMP
IMP: 通过突变表型推断
23591820 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18206972 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9603525 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of DUBm complex IDA
IDA: 通过直接分析推断
27601583 GOA
part of SAGA complex IDA
IDA: 通过直接分析推断
18206972 GOA
part of nuclear pore nuclear basket IDA
IDA: 通过直接分析推断
23591820 GOA
part of transcription export complex 2 IDA
IDA: 通过直接分析推断
23591820 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ENY2 蛋白结构

EnY2

EnY2: Transcription factor e(y)2 (11 - 95)

  • 0
  • 101 a.a.
蛋白主名 其他名称

transcription and mRNA export factor ENY2

enhancer of yellow 2 homolog

ENY2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ENY2 Q9NPA8 ATXN7L3 Homo sapiens Q14CW9
Y2H Array
32296183
种属内
ENY2 Q9NPA8 ATXN7L3 Homo sapiens Q14CW9
Anti Tag CoIP
35271311
种属内
ENY2 Q9NPA8 ATXN7L3 Homo sapiens Q14CW9
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 7

Spinocerebellar Ataxia Type 7

SCA7

Opca3

Opca Iii

Olivopontocerebellar Atrophy Iii

Opca With Retinal Degeneration

Opca With Macular Degeneration And External Ophthalmoplegia

Adca, Type Ii

Autosomal Dominant Cerebellar Ataxia Type 2

Olivopontocerebellar Atrophy 3

Autosomal Dominant Cerebellar Ataxia, Type Ii

Autosomal Dominant Cerebellar Ataxia Type Ii

Adca2

Adcaii

Ataxia With Pigmentary Retinopathy

Cerebellar Syndrome-Pigmentary Maculopathy Syndrome

Olivopontocerebellar Atrophy With Retinal Degeneration

Spinocerebellar Ataxia-7

Ataxia, Spinocerebellar, Type 7

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ENY2 RGD RGD:1596439
Macaca mulatta ENY2 VGNC VGNC:104451
Felis catus ENY2 VGNC VGNC:61886
Mus musculus ENY2 MGD MGI:1919286
Bos taurus ENY2 VGNC VGNC:28514