2. Gene
  3. PARP6 - poly(ADP-ribose) polymerase family member 6 Gene

PARP6 - poly(ADP-ribose) polymerase family member 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：聚 (ADP-核糖) 聚合酶家族成员 6

种属: Homo sapiens

同用名: ARTD17; pART17; PARP-6-C; PARP-6-B1

基因 ID: 56965 | 基因类型: protein coding

关于 PARP6

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:72,241,181-72,272,554 (from NCBI)

This gene has 23 transcripts (splice variants), 180 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 26.3), thyroid (RPKM 13.7) and 25 other tissues.

功能概要

启用蛋白质 ADP-核糖基酶活性。参与蛋白质自身-ADP-核糖基化和蛋白质单-ADP-核糖基化。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. [provided by Alliance of Genome Resources, Apr 2022]

PARP6 基因产物(14)

mRNA Protein Name
NM_001323515.2 NP_001310444.1 protein mono-ADP-ribosyltransferase PARP6 isoform 2
NM_001323516.2 NP_001310445.1 protein mono-ADP-ribosyltransferase PARP6 isoform 2
NM_001323519.2 NP_001310448.1 protein mono-ADP-ribosyltransferase PARP6 isoform 3
NM_001323521.2 NP_001310450.1 protein mono-ADP-ribosyltransferase PARP6 isoform 3
NM_001323522.2 NP_001310451.1 protein mono-ADP-ribosyltransferase PARP6 isoform 1
NM_001323523.2 NP_001310452.1 protein mono-ADP-ribosyltransferase PARP6 isoform 3
NM_001323524.2 NP_001310453.1 protein mono-ADP-ribosyltransferase PARP6 isoform 3
NM_001323525.2 NP_001310454.1 protein mono-ADP-ribosyltransferase PARP6 isoform 4
NM_001323526.2 NP_001310455.1 protein mono-ADP-ribosyltransferase PARP6 isoform 3
NM_001323528.2 NP_001310457.1 protein mono-ADP-ribosyltransferase PARP6 isoform 4
NM_001323530.2 NP_001310459.1 protein mono-ADP-ribosyltransferase PARP6 isoform 2
NM_001323531.2 NP_001310460.1 protein mono-ADP-ribosyltransferase PARP6 isoform 4
NM_001323532.2 NP_001310461.1 protein mono-ADP-ribosyltransferase PARP6 isoform 1
NM_020214.4 NP_064599.2 protein mono-ADP-ribosyltransferase PARP6 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD+-protein-aspartate ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
25043379 GOA
enables NAD+-protein-cysteine ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
25043379 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein auto-ADP-ribosylation IDA
IDA: 通过直接分析推断
25043379 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PARP6 蛋白结构

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (456 - 526)

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  • 500
  • 630 a.a.
蛋白主名 其他名称

protein mono-ADP-ribosyltransferase PARP6

ADP-ribosyltransferase diphtheria toxin-like 17

关联疾病

疾病名称 别名
Diphtheria

Corynebacterium Infections

Corynebacterium Infection

Diphtherial Infection

Infection Due To Corynebacterium Diphtheriae
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-119653 AZ9482 Inhibitor 98.07% 否
HY-12975 AZ6102 Inhibitor 99.65% 否
HY-100847 AZ0108 Inhibitor / 否
HY-145749 PARPYnD Inhibitor / 否
HY-RS10069 PARP6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PARP6 MGD MGI:1914537
Bos taurus PARP6 VGNC VGNC:53578
Canis familiaris PARP6 VGNC VGNC:59122
Felis catus PARP6 VGNC VGNC:104353
Rattus norvegicus PARP6 RGD RGD:1310937
Others PARP6 NCBI
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