TIGAR - TP53 induced glycolysis regulatory phosphatase Gene

中文名称：TP53 诱导糖酵解调节磷酸酶

种属: Homo sapiens

同用名: FR2BP; C12orf5

关于 TIGAR

功能概要

该基因作为 p53 肿瘤抑制途径的一部分进行调节，并编码一种蛋白质，其序列与降解果糖-2,6-二磷酸的糖酵解酶的二磷酸结构域具有序列相似性。该蛋白质通过阻断糖酵解并将途径引导至戊糖磷酸分流器来发挥作用。这种蛋白质的表达还保护细胞免受 DNA 损伤活性氧的影响，并提供一些保护免受 DNA 损伤诱导的细胞凋亡。包含该基因的 12p13.32 区域与 11q13.3 区域同源。[RefSeq 提供，2008 年 7 月]

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic Enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging Reactive Oxygen Species and provides some protection from DNA damage-induced Apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]