2. Gene
  3. CYSLTR2 - cysteinyl leukotriene receptor 2 Gene

CYSLTR2 - cysteinyl leukotriene receptor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：半胱氨酰白三烯受体 2

种属: Homo sapiens

同用名: HG57; CYSLT2; GPCR21; HPN321; CYSLT2R; KPG_011; hGPCR21; PSEC0146

基因 ID: 57105 | 基因类型: protein coding

关于 CYSLTR2

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:48,653,929-48,711,226 (from NCBI)

This gene has 6 transcripts (splice variants), 80 orthologues, 16 paralogues and is associated with 53 phenotypes. Broad expression in placenta (RPKM 7.8), heart (RPKM 2.8) and 17 other tissues.

功能概要

半胱氨酰白三烯 LTC4、LTD4 和 LTE4 是人类支气管哮喘的重要介质。药理学研究已经确定半胱氨酰白三烯激活至少 2 个受体，即由该基因编码的蛋白质和 CYSLTR1。这种编码的受体是 G 蛋白偶联受体超家族的成员。它似乎在内分泌和心血管系统中起着重要作用。[RefSeq 提供，2008 年 7 月]

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]

CYSLTR2 基因产物(11)

mRNA Protein Name
NM_001308476.3 NP_001295405.1 cysteinyl leukotriene receptor 2
NM_020377.5 NP_065110.1 cysteinyl leukotriene receptor 2
NM_001387013.1 NP_001373942.1 cysteinyl leukotriene receptor 2
NM_001308465.3 NP_001295394.1 cysteinyl leukotriene receptor 2
NM_001308468.3 NP_001295397.1 cysteinyl leukotriene receptor 2
NM_001308467.3 NP_001295396.1 cysteinyl leukotriene receptor 2
NM_001387014.1 NP_001373943.1 cysteinyl leukotriene receptor 2
NM_001308469.3 NP_001295398.1 cysteinyl leukotriene receptor 2
NM_001308471.3 NP_001295400.1 cysteinyl leukotriene receptor 2
NM_001308470.3 NP_001295399.1 cysteinyl leukotriene receptor 2
NM_001387012.1 NP_001373941.1 cysteinyl leukotriene receptor 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21525870 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CYSLTR2 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (55 - 305)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
蛋白主名 其他名称

cysteinyl leukotriene receptor 2

G-protein coupled receptor GPCR21

G-protein coupled receptor HG57

cysteinyl leukotriene CysLT2 receptor

CYSLTR2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CYSLTR2 Q9NS75 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
种属内
CYSLTR2 Q9NS75 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
种属内
CYSLTR2 Q9NS75 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
种属内
CYSLTR2 Q9NS75 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
种属内
CYSLTR2 Q9NS75 DLG1 Homo sapiens Q12959
TAP
26617989
种属内
CYSLTR2 Q9NS75 DLG1 Homo sapiens Q12959
Ub Reconstruction
21525870
种属内
CYSLTR2 Q9NS75 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
种属内
CYSLTR2 Q9NS75 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Conjunctival Cancer

Malignant Neoplasm Of Conjunctiva

Conjunctival Neoplasms

Conjunctival Tumor

Malignant Conjunctival Tumor

Malignant Tumor Of Conjunctiva

Neoplasm Of Conjunctiva

Conjunctiva Cancer

Primary Malignant Neoplasm Of Conjunctiva
Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris
Malignant Conjunctival Melanoma

Conjunctival Melanoma

Malignant Melanoma Of Conjunctiva

Conjunctival Malignant Melanoma
Vernal Conjunctivitis

Conjunctivitis Vernal

Conjunctivitis, Vernal
Asthma, Nasal Polyps, And Aspirin Intolerance

Asthma And Nasal Polyps

Asa Triad

Asthma, Aspirin-Induced, Susceptibility To

Asthma, Aspirin-Induced

Asthma, With Nasal Polyps And Aspirin Intolerance

ANPAI

Aia

Aspirin-Intolerant Asthma

Asthma Aspirin-Induced

Nasal Polyps Asthma And Aspirin Sensitivity

Samter Triad

Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps
Aspirin-Induced Respiratory Disease

Aspirin-Sensitive Asthma
Persistent Mild Asthma
Exercise-Induced Bronchoconstriction

Exercise-Induced Asthma

Asthma Exercise-Induced
Ocular Melanoma

Intraocular Melanoma

Uveal Melanoma

Eye Melanoma

Melanoma Of Eye

Melanoma Of The Uvea

Malignant Melanoma Of Eye
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Uveal Disease

Uveal Diseases
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03497 CYSLTR2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03498 Cysltr2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03499 Cysltr2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CYSLTR2 MGD MGI:1917336
Bos taurus CYSLTR2 VGNC VGNC:50271
Macaca mulatta CYSLTR2 VGNC VGNC:106256
Rattus norvegicus CYSLTR2 RGD RGD:619797
Canis familiaris CYSLTR2 VGNC VGNC:57504
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