2. Gene
  3. PSMD10 - proteasome 26S subunit, non-ATPase 10 Gene

PSMD10 - proteasome 26S subunit, non-ATPase 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白酶体 26S 亚基，非 ATPase 10

种属: Homo sapiens

同用名: p28; p28(GANK); dJ889N15.2

基因 ID: 5716 | 基因类型: protein coding

关于 PSMD10

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:108,084,207-108,091,542 (from NCBI)

This gene has 7 transcripts (splice variants), 225 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 23.6), thyroid (RPKM 20.0) and 25 other tissues.

功能概要

该基因编码 PA700/19S 复合体的一个亚基，它是 26S 蛋白酶体的调节成分。 26S 蛋白体复合物是泛素依赖性蛋白质降解所必需的。这种蛋白质是一种非 ATP 酶亚基，可能参与蛋白质-蛋白质相互作用。该基因的异常表达可能在肿瘤发生中起作用。已经描述了编码不同亚型的两个转录物。已在 3 号和 20 号染色体上鉴定出假基因。[RefSeq 提供，2011 年 3 月]

This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S Proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]

PSMD10 基因产物(2)

mRNA Protein Name
NM_002814.4 NP_002805.1 26S proteasome non-ATPase regulatory subunit 10 isoform 1
NM_170750.3 NP_736606.1 26S proteasome non-ATPase regulatory subunit 10 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10613832 GOA
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
18040287 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoplasmic sequestering of NF-kappaB IDA
IDA: 通过直接分析推断
18040287 GOA
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
IDA: 通过直接分析推断
16023600 GOA
involved in negative regulation of MAPK cascade IMP
IMP: 通过突变表型推断
19729910 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
18040287 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
16023600 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
19729910 GOA
involved in negative regulation of release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
19729910 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16023600 GOA
involved in positive regulation of cell growth IDA
IDA: 通过直接分析推断
10613832 GOA
involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
11900540 GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
16023600 GOA
involved in positive regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
16023600 GOA
involved in proteasome regulatory particle assembly IMP
IMP: 通过突变表型推断
19490896 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18040287 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18040287 GOA
part of proteasome complex IDA
IDA: 通过直接分析推断
17323924 GOA
part of proteasome regulatory particle, base subcomplex IDA
IDA: 通过直接分析推断
19490896 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PSMD10 蛋白结构

Ank_2

Ank_2: Ankyrin repeats (3 copies) (34 - 103)

Ank

Ank: Ankyrin repeat (105 - 136)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (139 - 201)

  • 0
  • 100
  • 200
  • 226 a.a.
蛋白主名 其他名称

26S proteasome non-ATPase regulatory subunit 10

26S proteasome regulatory subunit p28

重组 PSMD10 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70213 Gankyrin/PSMD10 Protein, Human O75832-1 (M1-G226) ≥95%

关联疾病

疾病名称 别名
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
Uterine Corpus Sarcoma

Sarcoma Of Corpus Uteri

Sarcoma Of Uterus

Sarcoma Of The Corpus Uteri

Uterine Sarcoma

Sarcoma, Nos Of Uterus
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11318 PSMD10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PSMD10 VGNC VGNC:97572
Canis familiaris PSMD10 VGNC VGNC:45106
Macaca mulatta PSMD10 VGNC VGNC:103851
Mus musculus PSMD10 MGD MGI:1858898
Rattus norvegicus PSMD10 RGD RGD:620350
Others PSMD10 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z