2. Gene
  3. Uts2r - urotensin 2 receptor Gene

Uts2r - urotensin 2 receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：尿压素2 受体

种属: Rattus norvegicus

同用名: Senr; Gpr14; UR-2-R

基因 ID: 57305 | 基因类型: protein coding

关于 Uts2r

Primary_assembly 10: 106,438,092-106,439,252 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 54 orthologues, 24 paralogues and is associated with 9 phenotypes.

功能概要

该基因编码的蛋白可启动 urotensin II 受体活性。参与多个过程，包括昼夜节律睡眠/觉醒周期的正向调节、REM 睡眠；昼夜节律睡眠/觉醒周期、觉醒的正向调节；和调节血压。位于早期内体；质膜;和回收核内体。用于研究急性肾功能衰竭；心内膜心肌纤维化；和高血压。心肌病和心肌梗塞的生物标志物。与人 UTS2R（urotensin 2 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables urotensin II receptor activity. Involved in several processes, including positive regulation of circadian sleep/wake cycle, REM sleep; positive regulation of circadian sleep/wake cycle, wakefulness; and regulation of blood pressure. Located in early endosome; plasma membrane; and recycling endosome. Used to study acute kidney failure; endomyocardial fibrosis; and hypertension. Biomarker of cardiomyopathy and myocardial infarction. Orthologous to human UTS2R (urotensin 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Uts2r 基因产物(1)

mRNA Protein Name
NM_020537.1 NP_065412.1 urotensin-2 receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables urotensin II receptor activity IDA
IDA: 通过直接分析推断
16141412 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of blood pressure IMP
IMP: 通过突变表型推断
16531985 RGD
involved in negative regulation of glomerular filtration IMP
IMP: 通过突变表型推断
16531985 RGD
involved in negative regulation of urine volume IMP
IMP: 通过突变表型推断
16531985 RGD
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
17089015 RGD
involved in positive regulation of blood pressure IMP
IMP: 通过突变表型推断
17900760 RGD
involved in positive regulation of cell growth IMP
IMP: 通过突变表型推断
15549273 RGD
involved in positive regulation of circadian sleep/wake cycle, REM sleep IMP
IMP: 通过突变表型推断
15944374 RGD
involved in positive regulation of circadian sleep/wake cycle, wakefulness IMP
IMP: 通过突变表型推断
15944374 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
15549273 RGD
involved in positive regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
16919371 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
15554454 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
17184580 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome IDA
IDA: 通过直接分析推断
16141412 RGD
located in recycling endosome IDA
IDA: 通过直接分析推断
16141412 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Uts2r 蛋白结构

7tmA_UII-R

7tmA_UII-R: cd14999 (53 - 78)

7tmA_UII-R

7tmA_UII-R: cd14999 (53 - 327)

7tmA_UII-R

7tmA_UII-R: cd14999 (85 - 109)

7tmA_UII-R

7tmA_UII-R: cd14999 (122 - 152)

7tmA_UII-R

7tmA_UII-R: cd14999 (164 - 185)

7tmA_UII-R

7tmA_UII-R: cd14999 (207 - 236)

7tmA_UII-R

7tmA_UII-R: cd14999 (251 - 281)

7tmA_UII-R

7tmA_UII-R: cd14999 (295 - 320)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
蛋白主名 其他名称

urotensin-2 receptor

G-protein coupled receptor 14

G-protein coupled sensory epithelial neuropeptide-like receptor

UR-II-R

putative G protein-coupled receptor (SENR)

urotensin II receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15584 UTS2R Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS15585 Uts2r Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS15586 Uts2r Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Uts2r NCBI NCBI:2837
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