PTGFR - prostaglandin F receptor Gene

中文名称：前列腺素 F 受体

种属: Homo sapiens

同用名: FP

基因 ID: 5737 | 基因类型: protein coding

关于 PTGFR

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:78,490,974-78,540,701 (from NCBI)

This gene has 4 transcripts (splice variants), 195 orthologues and 7 paralogues. Broad expression in endometrium (RPKM 7.8), urinary bladder (RPKM 5.1) and 16 other tissues.

功能概要

由该基因编码的蛋白质是 G 蛋白偶联受体家族的成员。这种蛋白质是前列腺素 F2-α (PGF2-alpha) 的受体，已知它是一种有效的黄体溶解剂，也可能参与调节眼内压和子宫平滑肌收缩。小鼠基因敲除研究表明，PGF2-α 与该受体的相互作用可能会启动卵巢黄体细胞的分娩，从而诱导黄体溶解。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PTGFR 基因产物(5)

mRNA	Protein	Name
NM_001039585.2	NP_001034674.1	prostaglandin F2-alpha receptor isoform b precursor
XM_047426101.1	XP_047282057.1	prostaglandin F2-alpha receptor isoform X3
XM_047426085.1	XP_047282041.1	prostaglandin F2-alpha receptor isoform X1
NM_000959.4	NP_000950.1	prostaglandin F2-alpha receptor isoform a precursor
XM_017001873.1	XP_016857362.1	prostaglandin F2-alpha receptor isoform X2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables prostaglandin F receptor activity	IDA IDA: 通过直接分析推断	18587449	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to prostaglandin D stimulus	IMP IMP: 通过突变表型推断	18508192	GOA
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	18508192	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	18508192	GOA
located in extracellular region	IDA IDA: 通过直接分析推断	10575000	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	18508192	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTGFR 蛋白结构

7tm_1

0
100
200
300
359 a.a.

蛋白主名

其他名称

prostaglandin F2-alpha receptor

FP prostanoid receptor	PGF receptor
PGF2 alpha receptor	prostaglandin receptor (2-alpha)
prostanoid FP receptor

关联疾病

疾病名称

别名

Ocular Hypertension

Hypertension, Ocular	Intraocular Pressure Increase
Oh - [Ocular Hypertension]	Oht - [Ocular Hypertension]

Intraocular Pressure Quantitative Trait Locus

Glaucoma	IOPQTL
Glaucoma, Susceptibility To	Postinfectious Glaucoma
Glaucoma With Ocular Inflammation	Glaucoma Secondary To Eye Inflammation
Traumatic Glaucoma	Glaucoma With Concussion Of Globe
Glaucoma Due To Ocular Trauma	Glaucoma Associated With Ocular Trauma
Glaucoma Secondary To Drugs

Open-Angle Glaucoma

Glaucoma Simplex	Pigmentary Glaucoma
Wide-Angle Glaucoma	Glaucoma, Open-Angle
Open Angle Glaucoma	Glaucoma Open-Angle
Chronic Simple Glaucoma	Coag - [Chronic Open-Angle Glaucoma]
Csg - [Chronic Simple Glaucoma]	Poag - [Primary Open-Angle Glaucoma]
Oag - [Open-Angle Glaucoma]	Chronic Glaucoma
Chronic Open Angle Glaucoma	Simple Glaucoma
Chronic Noncongestive Glaucoma	Ltg - [Low Tension Glaucoma]
Noncongestive Glaucoma	Nonobstructive Glaucoma
Normal Pressure Glaucoma	Primary Low Tension Glaucoma
Low-Tension Glaucoma	Residual Stage Low Tension Glaucoma
Open Cleft Glaucoma

Punctate Epithelial Keratoconjunctivitis

Punctate Keratitis	Thygeson Superficial Punctate Keratitis
Thygeson'S Superficial Punctate Keratitis	Thygeson Superficial Punctate Keratopathy
Punctate Epithelial Keratitis

Blepharoconjunctivitis

Glaucoma, Normal Tension

Low Tension Glaucoma	Glaucoma, Normal Tension, Susceptibility To
Normal Tension Glaucoma	Ntg
Glaucoma, Normal Pressure	NPG
Glaucoma, Normal Pressure, Susceptibility To	Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]

Enophthalmos

Ocular Hypotension

Hypotony Of Eye

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Ocular Hyperemia

Hyperemia Eye

Hyperemia Of Conjunctiva

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11382	PTGFR Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11383	Ptgfr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11384	Ptgfr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PTGFR	VGNC	VGNC:69143
Macaca mulatta	PTGFR	VGNC	VGNC:76584
Mus musculus	PTGFR	MGD	MGI:97796
Bos taurus	PTGFR	VGNC	VGNC:50251
Canis familiaris	PTGFR	VGNC	VGNC:45147
Rattus norvegicus	PTGFR	RGD	RGD:3436
Macaca fascicularis	PTGFR	NCBI	NCBI:102139926
Others	PTGFR	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PTGFR - prostaglandin F receptor Gene

关于 PTGFR

功能概要

PTGFR 基因产物(5)

PTGFR 蛋白结构

关联疾病

直系同源

热门区域

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PTGFR - prostaglandin F receptor Gene

关于 PTGFR

功能概要

PTGFR 基因产物(5)

PTGFR 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z