2. Gene
  3. SCYL1 - SCY1 like pseudokinase 1 Gene

SCYL1 - SCY1 like pseudokinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SCY1 样假激酶 1

种属: Homo sapiens

同用名: GKLP; NKTL; NTKL; P105; TAPK; TEIF; TRAP; HT019; SCAR21

基因 ID: 57410 | 基因类型: protein coding

关于 SCYL1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,525,083-65,538,704 (from NCBI)

This gene has 14 transcripts (splice variants), 183 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 23.2), ovary (RPKM 22.4) and 25 other tissues.

功能概要

该基因编码属于激酶样蛋白 SCY1 样家族的转录调节因子。该蛋白质具有一个不同的 N 末端激酶结构域，该结构域被认为没有催化活性，并且可以通过其 C 末端结构域结合特定的 DNA 序列。它激活端粒酶逆转录酶和 DNA 聚合酶 β 基因的转录。该蛋白质已定位于细胞核，在有丝分裂期间也定位于细胞质和中心体。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase Reverse Transcriptase and DNA Polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SCYL1 基因产物(3)

mRNA Protein Name
NM_001048218.2 NP_001041683.1 N-terminal kinase-like protein isoform B
NM_001411022.1 NP_001397951.1 N-terminal kinase-like protein isoform C
NM_020680.4 NP_065731.3 N-terminal kinase-like protein isoform A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
26871637 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IDA
IDA: 通过直接分析推断
18556652 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of COPI vesicle coat IDA
IDA: 通过直接分析推断
18556652 GOA
located in Golgi apparatus IDA
IDA: 通过直接分析推断
18556652 GOA
located in cis-Golgi network IDA
IDA: 通过直接分析推断
18556652 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: 通过直接分析推断
18556652 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SCYL1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (55 - 222)

  • 0
  • 200
  • 400
  • 600
  • 808 a.a.
蛋白主名 其他名称

N-terminal kinase-like protein

SCY1-like protein 1

SCYL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SCYL1 Q96KG9 SEC31A Homo sapiens O94979
Pull Down
32707033
种属内
SCYL1 Q96KG9 SEC31A Homo sapiens O94979
Anti Tag CoIP
35271311
种属内
SCYL1 Q96KG9 SEC31A Homo sapiens O94979
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinocerebellar Ataxia, Autosomal Recessive 21

SCAR21

Acute Infantile Liver Failure-Cerebellar Ataxia-Peripheral Sensory Motor Neuropathy Syndrome

Spinocerebellar Ataxia, Autosomal Recessive 21, With Hepatopathy

Cholestasis, Low Ggt, Acute Liver Failure, And Neurodegeneration Syndrome

Calfan

Autosomal Recessive Spinocerebellar Ataxia 21

Autosomal Recessive Spinocerebellar Ataxia 21 With Hepatopathy

Autosomal Recessive Spinocerebellar Ataxia Type 21

Spinocerebellar Ataxia, Autosomal Recessive, 21

Calfan Syndrome
Spinocerebellar Ataxia 21

Spinocerebellar Ataxia Type 21

SCA21

Ataxia, Spinocerebellar, Type 21
Geroderma Osteodysplasticum

Gerodermia Osteodysplastica

Geroderma Osteodysplastica

GO

Walt Disney Dwarfism

Type Of Gerodermia Osteodysplastica
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12575 SCYL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SCYL1 MGD MGI:1931787
Bos taurus SCYL1 VGNC VGNC:34374
Rattus norvegicus SCYL1 RGD RGD:1307330
Canis familiaris SCYL1 VGNC VGNC:45938
Felis catus SCYL1 VGNC VGNC:64940
Others SCYL1 NCBI
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