1. Gene
  2. AS3MT - arsenite methyltransferase Gene

AS3MT - arsenite methyltransferase Gene

中文名称:亚砷酸甲基转移酶

种属: Homo sapiens

同用名: CYT19

基因 ID: 57412 | 基因类型: protein coding

关于 AS3MT

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,869,470-102,901,899 (from NCBI)

This gene has 1 transcript (splice variant), 190 orthologues and 4 paralogues. Biased expression in adrenal (RPKM 88.8), liver (RPKM 11.0) and 5 other tissues.

功能概要

AS3MT 催化甲基从 S-腺苷-L-甲硫氨酸 (AdoMet) 转移到三价砷,并可能在砷代谢中发挥作用 (Lin 等人,2002 [PubMed 11790780]) 。[OMIM 提供,2008 年 3 月] ]

AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]

AS3MT 基因产物(1)

mRNA Protein Name
NM_020682.4 NP_065733.2 arsenite methyltransferase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables arsenite methyltransferase activity IDA
IDA: 通过直接分析推断
25997655 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in arsonoacetate metabolic process IDA
IDA: 通过直接分析推断
25997655 GOA
involved in methylation IDA
IDA: 通过直接分析推断
25997655 GOA
involved in toxin metabolic process IDA
IDA: 通过直接分析推断
25997655 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

AS3MT 蛋白结构

Methyltransf_31

Methyltransf_31: Methyltransferase domain (70 - 216)

  • 0
  • 100
  • 200
  • 300
  • 375 a.a.
蛋白主名 其他名称

arsenite methyltransferase

S-adenosyl-L-methionine:arsenic(III) methyltransferase

关联疾病

疾病名称 别名
Borst-Jadassohn Intraepidermal Carcinoma

Intraepidermal Epithelioma Of Jadassohn

Bowen'S Disease, Clonal

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta AS3MT VGNC VGNC:69856
Rattus norvegicus AS3MT RGD RGD:621325
Bos taurus AS3MT VGNC VGNC:97241
Felis catus AS3MT VGNC VGNC:59951
Mus musculus AS3MT MGD MGI:1929882