2. Gene
  3. ESYT2 - extended synaptotagmin 2 Gene

ESYT2 - extended synaptotagmin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：扩展突触结合蛋白 2

种属: Homo sapiens

同用名: E-Syt2; FAM62B; CHR2SYT

基因 ID: 57488 | 基因类型: protein coding

关于 ESYT2

Cytogenetic location: 7q36.3 Genomic coordinates (GRCh38): 7:158,730,997-158,829,509 (from NCBI)

This gene has 6 transcripts (splice variants), 286 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 29.7), thyroid (RPKM 27.6) and 25 other tissues.

功能概要

启用钙离子结合活性；相同的蛋白质结合活性；和磷脂结合活性。预计参与内吞作用；内质网-质膜束缚；和脂质运输。位于内质网-质膜接触部位。是质膜细胞质侧的外在成分；质膜的组成部分；和内质网膜的固有成分。 [由基因组资源联盟提供，2022 年 4 月]

Enables calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in endocytosis; endoplasmic reticulum-plasma membrane tethering; and lipid transport. Located in endoplasmic reticulum-plasma membrane contact site. Is extrinsic component of cytoplasmic side of plasma membrane; integral component of plasma membrane; and intrinsic component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

ESYT2 基因产物(2)

mRNA Protein Name
NM_001367773.1 NP_001354702.1 extended synaptotagmin-2 isoform 1
NM_020728.3 NP_065779.2 extended synaptotagmin-2 isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
24373768 GOA
enables calcium-dependent phospholipid binding IDA
IDA: 通过直接分析推断
17360437 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
23791178 GOA
enables phosphatidylcholine binding IDA
IDA: 通过直接分析推断
24847877 GOA
enables phosphatidylethanolamine binding IDA
IDA: 通过直接分析推断
24847877 GOA
enables phosphatidylinositol binding IDA
IDA: 通过直接分析推断
24847877 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22119785 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic side of plasma membrane IMP
IMP: 通过突变表型推断
23791178 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
23791178 GOA
located in endoplasmic reticulum-plasma membrane contact site IDA
IDA: 通过直接分析推断
27044890 GOA
located in organelle membrane contact site IDA
IDA: 通过直接分析推断
23791178 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17360437 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ESYT2 蛋白结构

C2

C2: C2 domain (359 - 443)

C2

C2: C2 domain (516 - 583)

C2

C2: C2 domain (776 - 854)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 893 a.a.
蛋白主名 其他名称

extended synaptotagmin-2

chr2 synaptotagmin

ESYT2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ESYT2 A0FGR8 ESYT2 Homo sapiens A0FGR8
Anti Tag CoIP
23791178
种属内
ESYT2 A0FGR8 ESYT2 Homo sapiens A0FGR8
Ion Mobility Mass Spec
24847877
种属内
ESYT2 A0FGR8 ESYT2 Homo sapiens A0FGR8
X-Ray Diffraction
24847877
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Short-Rib Thoracic Dysplasia 8 With Or Without Polydactyly

SRTD8

Srps6

Short Rib-Polydactyly Syndrome Type Vi

Short Rib-Polydactyly Syndrome, Type Vi

Srps Type Vi
B-Lymphoblastic Leukemia/Lymphoma Mll Rearranged

B-Lymphoblastic Leukemia/Lymphoma Kmt2a Rearranged

B Lymphoblastic Leukemia/Lymphoma With T

Mll Rearranged

B-All Kmt2a Rearranged

B-Lymphoblastic Leukemia/Lymphoma With T

Kmt2a Rearranged
Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome

Duane'S Syndrome

Duane Syndrome

Isolated Duane Retraction Syndrome

Co-Contractive Retraction Syndrome

Duane Anomaly, Isolated

Ocular Retraction Syndrome

Drs

Durs
Asphyxiating Thoracic Dystrophy

Jeune Thoracic Dystrophy

Jeune Syndrome

Asphyxiating Thoracic Dysplasia

Short-Rib Thoracic Dysplasia With Or Without Polydactyly

Thoracic Pelvic Phalangeal Dystrophy

Asphyxiating Thoracic Chondrodystrophy

Atd

Chondroectodermal Dysplasia-Like Syndrome

Infantile Thoracic Dystrophy

Jeune Thoracic Dysplasia

Thoracic Asphyxiant Dystrophy

Thoracic-Pelvic-Phalangeal Dystrophy

Short-Rib Thoracic Dysplasia Without Polydactyly

Asphyxiating Thoracic Dystrophy Of The Newborn

Asphyxiating Thorax Dystrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04549 ESYT2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ESYT2 VGNC VGNC:72316
Felis catus ESYT2 VGNC VGNC:61972
Bos taurus ESYT2 VGNC VGNC:28614
Rattus norvegicus ESYT2 RGD RGD:1565705
Canis familiaris ESYT2 VGNC VGNC:40484
Mus musculus ESYT2 MGD MGI:1261845
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