2. Gene
  3. AHRR - aryl hydrocarbon receptor repressor Gene

AHRR - aryl hydrocarbon receptor repressor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：芳烃受体阻遏物

种属: Homo sapiens

同用名: AHH; AHHR; bHLHe77

基因 ID: 57491 | 基因类型: protein coding

关于 AHRR

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:321,714-438,285 (from NCBI)

This gene has 11 transcripts (splice variants), 227 orthologues and 1 paralogue. Broad expression in testis (RPKM 4.1), spleen (RPKM 2.9) and 21 other tissues.

功能概要

该基因编码的蛋白质参与介导二恶英毒性的芳烃受体 (AhR) 信号级联反应，并参与细胞生长和分化的调节。它通过抑制 AhR 依赖性基因表达作为反馈调节剂发挥作用。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 6 月]

The protein encoded by this gene participates in the Aryl Hydrocarbon Receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

AHRR 基因产物(2)

mRNA Protein Name
NM_001377236.1 NP_001364165.1 aryl hydrocarbon receptor repressor
NM_001377239.1 NP_001364168.1 aryl hydrocarbon receptor repressor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28904176 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AHRR 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (38 - 79)

PAS

PAS: PAS fold (116 - 179)

  • 0
  • 200
  • 400
  • 600
  • 701 a.a.
蛋白主名 其他名称

aryl hydrocarbon receptor repressor

ahR repressor

关联疾病

疾病名称 别名
Aryl Hydrocarbon Hydroxylase Inducibility

Ahh Inducibility

Ahhi
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00484 AHRR Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W517092 1,2,3,4,7,8,9-Heptachlorodibenzofuran / 否
HY-W775354 1,2,3,4,7,8-Hexachlorodibenzofuran / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus AHRR MGD MGI:1333776
Macaca mulatta AHRR VGNC VGNC:108143
Felis catus AHRR VGNC VGNC:101455
Canis familiaris AHRR VGNC VGNC:37729
Rattus norvegicus AHRR RGD RGD:1559857
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