2. Gene
  3. XPO5 - exportin 5 Gene

XPO5 - exportin 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：输出 5

种属: Homo sapiens

同用名: exp5

基因 ID: 57510 | 基因类型: protein coding

关于 XPO5

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,522,334-43,576,038 (from NCBI)

This gene has 12 transcripts (splice variants), 224 orthologues and 1 paralogue. Broad expression in testis (RPKM 18.4), thyroid (RPKM 10.1) and 25 other tissues.

功能概要

该基因编码 karyopherin 家族的一个成员，该家族是将小 RNA 和双链 RNA 结合蛋白从细胞核运输到细胞质所必需的。编码的蛋白质在 RanGTP 依赖过程中通过核孔复合物转运货物。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]

XPO5 基因产物(1)

mRNA Protein Name
NM_020750.3 NP_065801.1 exportin-5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RISC complex binding IDA
IDA: 通过直接分析推断
19965479 GOA
enables mRNA binding IDA
IDA: 通过直接分析推断
21297638 GOA
enables nuclear export signal receptor activity IMP
IMP: 通过突变表型推断
14681208 GOA
contributes to pre-miRNA binding IDA
IDA: 通过直接分析推断
14681208 GOA
enables pre-miRNA binding IDA
IDA: 通过直接分析推断
21297638 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11777942 GOA
enables small GTPase binding IDA
IDA: 通过直接分析推断
11777942 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
14681208 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in pre-miRNA export from nucleus IDA
IDA: 通过直接分析推断
15613540 GOA
involved in pre-miRNA export from nucleus IMP
IMP: 通过突变表型推断
14681208 GOA
involved in protein export from nucleus IDA
IDA: 通过直接分析推断
11777942 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RISC complex IDA
IDA: 通过直接分析推断
19965479 GOA
part of RNA nuclear export complex IDA
IDA: 通过直接分析推断
14681208 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
11777942 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11777942 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

XPO5 蛋白结构

Xpo1

Xpo1: Exportin 1-like protein (110 - 271)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1204 a.a.
蛋白主名 其他名称

exportin-5

ran-binding protein 21

XPO5 抗体

目录号 产品名 应用 反应物种
HY-P82355 Exportin 5 Antibody (YA2100) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Pleuropulmonary Blastoma

PPB

Ppb Familial Tumor And Dysplasia Syndrome

Ppbftds

Pulmonary Blastoma

Blastoma, Pleuropulmonary

Dicer1 Syndrome

Respiratory Tract Neoplasms
Chromosomal Deletion Syndrome
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15891 XPO5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus XPO5 VGNC VGNC:67113
Rattus norvegicus XPO5 RGD RGD:1311522
Canis familiaris XPO5 VGNC VGNC:48462
Macaca mulatta XPO5 VGNC VGNC:79081
Bos taurus XPO5 VGNC VGNC:36999
Mus musculus XPO5 MGD MGI:1913789
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