2. Gene
  3. TAOK1 - TAO kinase 1 Gene

TAOK1 - TAO kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TAO 激酶 1

种属: Homo sapiens

同用名: DDIB; PSK2; TAO1; KFC-B; MARKK; PSK-2; hKFC-B; hTAOK1; MAP3K16

基因 ID: 57551 | 基因类型: protein coding

关于 TAOK1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:29,390,363-29,551,903 (from NCBI)

This gene has 6 transcripts (splice variants), 278 orthologues, 35 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 14.1), thyroid (RPKM 11.3) and 25 other tissues.

功能概要

启用 alpha-tubulin 绑定活动； β-微管蛋白结合活性；和激酶活性。参与多个过程，包括有丝分裂 G2 DNA 损伤检查点信号；微管解聚的负调节；和 JNK 级联的正调控。位于微管细胞骨架和细胞质核周区。 [由基因组资源联盟提供，2022 年 4 月]

Enables alpha-tubulin binding activity; beta-tubulin binding activity; and kinase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; negative regulation of microtubule depolymerization; and positive regulation of JNK cascade. Located in microtubule Cytoskeleton and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TAOK1 基因产物(2)

mRNA Protein Name
NM_020791.4 NP_065842.1 serine/threonine-protein kinase TAO1 isoform 1
NM_025142.1 NP_079418.1 serine/threonine-protein kinase TAO1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alpha-tubulin binding IDA
IDA: 通过直接分析推断
12639963 GOA
enables beta-tubulin binding IDA
IDA: 通过直接分析推断
12639963 GOA
enables kinase activity IDA
IDA: 通过直接分析推断
12639963 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11733138 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
17396146 GOA
involved in central nervous system neuron development IMP
IMP: 通过突变表型推断
33565190 GOA
involved in execution phase of apoptosis IDA
IDA: 通过直接分析推断
16407310 GOA
involved in microtubule cytoskeleton organization IMP
IMP: 通过突变表型推断
12639963 GOA
involved in mitotic G2 DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
17396146 GOA
involved in negative regulation of microtubule depolymerization IMP
IMP: 通过突变表型推断
12639963 GOA
involved in neuron cellular homeostasis IMP
IMP: 通过突变表型推断
17900936 GOA
involved in phosphorylation IDA
IDA: 通过直接分析推断
12639963 GOA
involved in positive regulation of JNK cascade IDA
IDA: 通过直接分析推断
16407310 GOA
involved in positive regulation of protein acetylation IMP
IMP: 通过突变表型推断
12639963 GOA
involved in positive regulation of stress-activated MAPK cascade IMP
IMP: 通过突变表型推断
17396146 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in microtubule cytoskeleton IMP
IMP: 通过突变表型推断
12639963 GOA
located in perinuclear region of cytoplasm IMP
IMP: 通过突变表型推断
12639963 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TAOK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (29 - 280)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1001 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase TAO1

MARK Kinase

TAOK1 抗体

目录号 产品名 应用 反应物种
HY-P82915 Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660) WB, IHC-P Human, Mouse, Rat
HY-P83514 TAOK1 Antibody (YA3259) WB, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Developmental Delay With Or Without Intellectual Impairment Or Behavioral Abnormalities

DDIB
Autosomal Dominant Non-Syndromic Intellectual Disability
Macroglossia

Congenital Macroglossia

Enlarged Tongue

Giant Tongue

Acquired Macroglossia Nos

Congenital Hypertrophy Of Tongue
Fanconi Anemia, Complementation Group C

Fanconi Anemia Complementation Group C

FANCC

Facc

Fac

Fa3

Fanconi Pancytopenia Type 3

Fanconi Pancytopenia, Type 3

Faces Syndrome

Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies

Friedman-Goodman Syndrome

Abnormality Of The Face
Syndromic X-Linked Intellectual Disability Lubs Type

Lubs X-Linked Mental Retardation Syndrome

Mecp2 Duplication Syndrome

Mental Retardation, X-Linked, Syndromic, Lubs Type

Mental Retardation, X-Linked, With Recurrent Respiratory Infections

Mrxsl

X-Linked Intellectual Disability-Hypotonia-Recurrent Infections Syndrome

Mental Retardation, X-Linked Syndromic, Lubs Type
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112136 TAO Kinase inhibitor 1 Inhibitor 99.46% 否
HY-RS14198 TAOK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TAOK1 VGNC VGNC:97653
Macaca mulatta TAOK1 VGNC VGNC:81591
Bos taurus TAOK1 VGNC VGNC:35595
Mus musculus TAOK1 MGD MGI:1914490
Rattus norvegicus TAOK1 RGD RGD:708455
Canis familiaris TAOK1 VGNC VGNC:47102
Others TAOK1 NCBI
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