2. Gene
  3. NLGN2 - neuroligin 2 Gene

NLGN2 - neuroligin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经胶质素 2

种属: Homo sapiens

基因 ID: 57555 | 基因类型: protein coding

关于 NLGN2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,404,653-7,419,860 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 237 orthologues and 13 paralogues. Broad expression in brain (RPKM 29.8), endometrium (RPKM 15.7) and 20 other tissues.

功能概要

该基因编码神经元细胞表面蛋白家族的一个成员。该家族的成员可作为 β-神经肽的剪接位点特异性配体，并可能参与中枢神经系统突触的形成和重塑。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

NLGN2 基因产物(1)

mRNA Protein Name
NM_020795.4 NP_065846.1 neuroligin-2 precursor
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
22528485 GOA
acts upstream of or within positive regulation of protein localization to synapse IDA
IDA: 通过直接分析推断
24613359 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NLGN2 蛋白结构

COesterase

COesterase: Carboxylesterase family (40 - 601)

  • 0
  • 200
  • 400
  • 600
  • 835 a.a.
蛋白主名 其他名称

neuroligin-2

关联疾病

疾病名称 别名
Pitt-Hopkins-Like Syndrome 1

Cortical Dysplasia-Focal Epilepsy Syndrome

CDFES

PTHSL1

Cdfe Syndrome

Pitt-Hopkins Like Syndrome 1

Pitt-Hopkins-Like Syndrome-1

Cntnap2-Related Developmental And Epileptic Encephalopathy

Cntnap2-Related Dee

Mesh

D006985

Mesh

D008607
Pervasive Developmental Disorder

Pervasive Development Disorder

Pervasive Developmental Disorders

Pervasive Child Development Disorders

Autistic Behavior

Autism Spectrum Disorders
Hyperekplexia

Hereditary Hyperekplexia

Kok Disease

Congenital Stiff Man Syndrome

Familial Startle Disease

Sthe

Stiff-Baby Syndrome

Hereditary Hyperexplexia

Startle Disease

Exaggerated Startle Reaction

Hyperexplexia Hereditary

Startle Disease, Familial

Startle Reaction, Exaggerated

Stiff-Man Syndrome, Congenital

Stiff-Person Syndrome, Congenital

Congenital Stiff-Man Syndrome

Congenital Stiff-Person Syndrome

Familial Hyperekplexia

Startle Syndrome

Stiff Baby Syndrome

Hyperekplexia, Hereditary

Stiff-Person Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09340 NLGN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NLGN2 MGD MGI:2681835
Felis catus NLGN2 VGNC VGNC:63822
Canis familiaris NLGN2 VGNC VGNC:43839
Bos taurus NLGN2 VGNC VGNC:55861
Macaca mulatta NLGN2 VGNC VGNC:104635
Rattus norvegicus NLGN2 RGD RGD:621118
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